Featured Research

from universities, journals, and other organizations

Anti-inflammatory Drug Prevents Liver Cancer In At-risk Liver Patients

Date:
September 11, 2006
Source:
John Wiley & Sons, Inc.
Summary:
Colchicine, an anti-inflammatory drug most often used to treat gout, prevented liver cancer in patients with hepatitis virus-related end-stage liver disease, according to a new study.

Colchicine, an anti-inflammatory drug most often used to treat gout, prevented liver cancer in patients with hepatitis virus-related end-stage liver disease, according to a new study. Published in the October 15, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study found that over three years of follow-up, patients with viral cirrhosis treated with colchicine were significantly less likely to be diagnosed with hepatocellular carcinoma (HCC) than those who did not receive the treatment, and significantly delayed the onset of HCC in patients who did develop the disease.

HCC is the fifth leading cancer worldwide and causes over 1 million deaths per year. The primary risk factor for HCC is fibrotic liver disease, or cirrhosis. Hepatitis viruses B and C are also major risk factors, as are metabolic diseases that affect the liver. Liver disease has a wide clinical spectrum, from mild abnormal lab results to irreversible fibrosis of the liver. Much of the damage to the liver is caused by inflammation, which can be caused by acute or chronic toxin exposure or infection. Inflammation is also implicated in the progression of HCC.

Colchicine is an anti-inflammatory drug commonly used to treat diseases such as gout and psoriasis. Animal studies have found that it also inhibits fibrosis formation in the liver. However, human trials on patients with liver cirrhosis demonstrated no significant efficacy in liver disease progression. Its effect on HCC prevention and progression has never been studied.

Led by Oscar Arrieta, M.D. of the Instituto Nacional de Cancerologνa in Mexico City, researchers evaluated colchicine as a drug to prevent HCC in patients with liver cirrhosis. They reviewed data from 186 patients with cirrhosis of the liver due to viral disease, of whom 116 were treated with colchicine.

They found that only about one in ten (9 percent) of patients treated with colchicine developed HCC compared to more than one in four (29 percent) of untreated cirrhotic patients. In addition, if subjects developed HCC, patients who were treated with colchicine developed HCC later than those not treated with the drug. Colchicine chemoprevention delayed the diagnosis of HCC after cirrhosis onset by an average 72 months (222 months compared to 150 months). Furthermore, colchicine-treated patients survived longer than untreated patients.

These findings, according to the authors, "demonstrate that colchicine can prevent the development of HCC, independently from other factors such as age, platelet count, alpha-FP and transaminase levels."


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Anti-inflammatory Drug Prevents Liver Cancer In At-risk Liver Patients." ScienceDaily. ScienceDaily, 11 September 2006. <www.sciencedaily.com/releases/2006/09/060911013549.htm>.
John Wiley & Sons, Inc.. (2006, September 11). Anti-inflammatory Drug Prevents Liver Cancer In At-risk Liver Patients. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2006/09/060911013549.htm
John Wiley & Sons, Inc.. "Anti-inflammatory Drug Prevents Liver Cancer In At-risk Liver Patients." ScienceDaily. www.sciencedaily.com/releases/2006/09/060911013549.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) — A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) — A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) — A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins