Featured Research

from universities, journals, and other organizations

Newly Identified Antibody May Neutralize Inhalation Anthrax Toxin

Date:
October 19, 2006
Source:
American Society For Microbiology
Summary:
A newly identified antibody capable of neutralizing the inhalation anthrax toxin in rabbits and monkeys may offer an alternative method of preventing and treating infection in humans say US researchers. Their findings appear in the October 2006 issue of the journal Infection and Immunity.

A newly identified antibody capable of neutralizing the inhalation anthrax toxin in rabbits and monkeys may offer an alternative method of preventing and treating infection in humans say US researchers. Their findings appear in the October 2006 issue of the journal Infection and Immunity.

Related Articles


The intentional use of Bacillus anthracis, the causative agent of anthrax, continues to pose serious threat as a bioterrorism or biowarfare agent. Although vaccines currently available are highly effective, multiple doses are required therefore necessitating antibiotic therapy for those individuals exposed prior to scheduled completion.

Monoclonal antibodies (MAb) are derived from one clone of cells, recognize only one antigen (the protective antigen (PA) component of the anthrax toxin combines with the lethal factor for cell entry) and are described as highly specific and purified. In the study the fully human MAb (now recognized at MAb 1303) was selected after neutralizing the anthrax toxin in transgenic mice. MAb 1303 was then found to offer effective postsymptomatic treatment in rabbits exposed to aerosolized anthrax spores as well as serve as a protective agent in monkeys challenged with aerosolized anthrax spores following a single intramuscular injection.

"Selection of an anti-PA MAb by using a functional assay that is a surrogate for protection has resulted in the identification of a fully human MAb with potent activity in vivo and uncovered a previously unrecognized mechanism of antibody-mediated toxin neutralization that is important for currently used anthrax vaccines," say the researchers.

(L. Vitale, D. Blanset, I. Lowy, T. O'Neill, J. Goldstein, S.F. Little, G.P. Andrews, G. Dorough, R.K. Taylor, T. Keler. 2006. Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity. Infection and Immunity, 74.10: 5840-5847.)


Story Source:

The above story is based on materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society For Microbiology. "Newly Identified Antibody May Neutralize Inhalation Anthrax Toxin." ScienceDaily. ScienceDaily, 19 October 2006. <www.sciencedaily.com/releases/2006/10/061018151159.htm>.
American Society For Microbiology. (2006, October 19). Newly Identified Antibody May Neutralize Inhalation Anthrax Toxin. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2006/10/061018151159.htm
American Society For Microbiology. "Newly Identified Antibody May Neutralize Inhalation Anthrax Toxin." ScienceDaily. www.sciencedaily.com/releases/2006/10/061018151159.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins