Featured Research

from universities, journals, and other organizations

Tarantula Venom And Chili Peppers Target Same Pain Sensor

Date:
November 9, 2006
Source:
University of California - San Francisco
Summary:
Venom from a West Indian tarantula has been shown to cause pain by exciting the same nerve cells in mice that sense high temperatures and the hot, spicy ingredient in chili peppers, UCSF scientists have discovered.

Trinidad chevron tarantula.
Credit: Image courtesy of University of California - San Francisco

Venom from a West Indian tarantula has been shown to cause pain by exciting the same nerve cells in mice that sense high temperatures and the hot, spicy ingredient in chili peppers, UCSF scientists have discovered.

The findings demonstrate that some plants and animals have evolved the same molecular strategy to deter predators -- triggering pain by activating a specific receptor on sensory nerves. The research provides new tools to understand how these pain- and heat-sensing neurons work, and to help develop drugs that ease persistent pain, the scientists report. Their finding, based on studies of mice cells in culture and live mice, is published in the November 9 issue of the journal Nature. The senior author is David Julius, professor and chair of physiology at UCSF.

The tarantula venom targets the heat sensor on nerve cells known as the capsaicin receptor, first cloned in 1997 in the Julius laboratory. In the last 10 years, Julius and his colleagues have demonstrated that this and related receptors trigger nerves to fire pain signals when exposed to Death Valley-like heat or the fiery properties of peppery food, mustard oil and other compounds. Human pain-sensing neurons also have these receptors on their surface, and some pain treatments have been developed that target them.

The capsaicin receptor acts as a channel on the nerve surface. When certain compounds bind to it, the receptor channel opens, allowing a stream of charged sodium and calcium molecules to rush into the nerve cell. This generates an electrical signal that travels to the brain to produce pain.

The researchers examined venoms from 22 spider and scorpion species whose bites are known to cause pain. Venom from the tarantula Psalmopoeus cambridgei activated the capsaicin receptor, also called TRPV1, and the researchers identified three protein subunits or peptides in the venom that targeted the receptor to cause pain. They also showed that venom from a second spider activated TRPV1, but they did not pinpoint which peptides were responsible.

The fact that a second spider venom triggered a capsaicin receptor suggests that a variety of spider species may have evolved the ability to use such toxins to target heat- and pain-sensing neuron receptors, the scientists conclude.

"It is fascinating that plants and animals have evolved the same anti-predatory mechanism to generate noxious sensations," Julius said. "These toxins are incredibly useful for understanding how ion channels of the nervous system work. They give us clues as to how specific activators or blockers on these channels can be designed to treat persistent pain -- from arthritis, bladder infections, or other diseases."

The researchers determined the venom peptides' effect in neuron cell cultures, measuring the tell-tale rush of calcium ions when the venom peptides contacted the TRPV1 capsaicin receptor. They also showed that synthetic versions of the venom peptides activated the receptor. In studies with mice, they found that normal animals flinched when their paws were exposed to the peptides, which they call vanillotoxins. Mice genetically engineered to lack capsaicin receptors did not respond.

Lead author of the Nature paper is Jan Siemens, PhD, postdoctoral scientist in cellular and molecular pharmacology at UCSF. Co-authors are Sharleen Zhou and David King at UC Berkeley; Rebecca Piskorowski, Columbia University; Tetsuro Nikai, PhD, a postdoctoral fellow in anatomy and physiology, UCSF; Ellen Lumpkin, PhD, assistant professor of neuroscience at Baylor College of Medicine; and Allan Basbaum, PhD, professor and chair of anatomy, UCSF.

The research was supported, in part, by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of California - San Francisco. Note: Materials may be edited for content and length.


Cite This Page:

University of California - San Francisco. "Tarantula Venom And Chili Peppers Target Same Pain Sensor." ScienceDaily. ScienceDaily, 9 November 2006. <www.sciencedaily.com/releases/2006/11/061108154516.htm>.
University of California - San Francisco. (2006, November 9). Tarantula Venom And Chili Peppers Target Same Pain Sensor. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2006/11/061108154516.htm
University of California - San Francisco. "Tarantula Venom And Chili Peppers Target Same Pain Sensor." ScienceDaily. www.sciencedaily.com/releases/2006/11/061108154516.htm (accessed September 17, 2014).

Share This



More Plants & Animals News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Raw: Scientists Examine Colossal Squid

Raw: Scientists Examine Colossal Squid

AP (Sep. 16, 2014) Squid experts in New Zealand thawed and examined an unusual catch on Tuesday: a colossal squid. It was captured in Antarctica's remote Ross Sea in December last year and has been frozen for eight months. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins