Featured Research

from universities, journals, and other organizations

New Biomarkers For Lupus Found

Date:
November 11, 2006
Source:
Wake Forest University Baptist Medical Center
Summary:
A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease.

A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease.

Related Articles


The biomarkers are micro-ribonucleic acids (micro-RNAs), said Nilamadhab Mishra, M.D. He and colleagues reported at the American College of Rheumatology meeting in Washington that they had found profound differences in the expression of micro-RNAs between five lupus patients and six healthy control patients who did not have lupus.

"We are the first to show that these micro-RNAs are a problem in human lupus," said Mishra, an assistant professor of rheumatology.

Mishra said microRNAs are a class of small chains of ribonucleic acid that have important regulatory functions in the body, particularly in suppressing genes. (RNA serves as the template for translation of genes into proteins.)

The research is part of Mishra's broader focus on histones, the tiny spools in the nuclei of cells around which DNA winds and compacts when it is not in the process of copying in cell division. Changes in these histones, called epigentic changes, can alter gene expression and the proteins these genes produce without altering the underlying DNA.

In the new study, the researchers found 40 microRNAs in which the difference in expression between the lupus patients and the controls was more than 1.5 times, and focused on five micro-RNAs where the lupus patients had more than three times the amount of the microRNAs as healthy controls, and one, called miR 95 where the lupus patients had just one third of the gene expression of the microRNA of the controls.

The team reported the lesser amount of miR 95 "results in aberrant gene expression in lupus patients."

Furthermore, Mishra said, the microRNAs are associated with enzymes called histone deacetylases which provide "further rationale for the use of histone deacetylase inhibitors (HDIs) for the treatment of lupus."

Mishra has shown that HDIs reset the histone modifications. He and his colleagues are investigating two HDIs -- TSA (Trichostatin A) and SAHA (suberoylanilide hydroxamic acid ) -- in lupus patients and have reported positive results against a number of lupus symptoms and conditions.

Coauthors with Mishra on this study are Kerri Keiger, Ph.D., and Emmanuel Labourier, Ph.D., of Ambion Inc. in Austin, Texas, which makes RNA-based research products for the life sciences markets.

In a second presentation, Mishra discussed his hypothesis that environmental factors trigger histone modifications that activate a type of white blood cell called the B cell and turn these cells into self-destructive attackers, a key element in lupus, an autoimmune disorder.

Mishra said removing these activated B cells is one current treatment for lupus. "The lupus patients have activated B cells that cause antibody production and kidney disease, but we don't know why," he said.

But he is continuing to pursue resetting part of the epigenetic code as a way to improve lupus treatment.

"We demonstrated that the response to bacterial and viral byproducts induce B-cell activation through the epigenetic mechanism," he said. These changes lead to activation of the histone deacetylase enzymes. The HDIs stop this activation.

Working with Mishra on this project is Isaac Snowhite, Ph.D., of Wake Forest.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "New Biomarkers For Lupus Found." ScienceDaily. ScienceDaily, 11 November 2006. <www.sciencedaily.com/releases/2006/11/061110092223.htm>.
Wake Forest University Baptist Medical Center. (2006, November 11). New Biomarkers For Lupus Found. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2006/11/061110092223.htm
Wake Forest University Baptist Medical Center. "New Biomarkers For Lupus Found." ScienceDaily. www.sciencedaily.com/releases/2006/11/061110092223.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins