Featured Research

from universities, journals, and other organizations

Risk Of Spina Bifida Associated With Choline Metabolism Genes, But Unrelated To Choline Intake

Date:
December 22, 2006
Source:
BioMed Central
Summary:
A new study finds an association between two genes involved in choline metabolism and the risk of spina bifida. The study, published in the open access journal BMC Medicine, also shows that this association is independent of dietary choline intake by the mother during pregnancy.

A new study finds an association between two genes involved in choline metabolism and the risk of spina bifida. The study, published in the open access journal BMC Medicine, also shows that this association is independent of dietary choline intake by the mother during pregnancy.

Choline is a nutrient, essential for cardiovascular and brain function, and for cellular membrane composition and repair. Often taken as a lecithin supplement, choline is found in beef liver, egg yolk, peanuts, sunflower seeds, cauliflower and soy. Recent studies had suggested that choline intake during pregnancy might decrease the risk of spina bifida.

James Enaw, from the Texas A&M University System Health Science Center in Houston, Texas and colleagues from the California Birth Defects Monitoring Program, analyzed the presence of two specific variants of the genes encoding the enzymes human choline esterase A (CHKA) and CTP:Phosphocholine cytidylytransferase(PCYT1A) in 103 infants suffering from spina bifida and 338 unaffected infants, who served as controls.

Although the study had limited statistical power, Enaw et al.'s results show that one variant of CHKA is associated with a reduced risk of spina bifida and one variant of PCYTA1A is associated with a two-fold increased risk of spina bifida. Interestingly, these associations are not modified by intake of choline by the mother during pregnancy.

The authors conclude: "The results indicate that dietary choline and choline metabolism genes may affect the risk of spina bifida independently or through some other unknown mechanisms."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Risk Of Spina Bifida Associated With Choline Metabolism Genes, But Unrelated To Choline Intake." ScienceDaily. ScienceDaily, 22 December 2006. <www.sciencedaily.com/releases/2006/12/061221074936.htm>.
BioMed Central. (2006, December 22). Risk Of Spina Bifida Associated With Choline Metabolism Genes, But Unrelated To Choline Intake. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2006/12/061221074936.htm
BioMed Central. "Risk Of Spina Bifida Associated With Choline Metabolism Genes, But Unrelated To Choline Intake." ScienceDaily. www.sciencedaily.com/releases/2006/12/061221074936.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins