Featured Research

from universities, journals, and other organizations

Tumor Cells Evade Death Through Autophagy

Date:
January 22, 2007
Source:
Journal Of Clinical Investigation
Summary:
Autophagy is a cellular process that enables cells to turnover their contents, something that they do frequently. Autophagy is initiated in tumor cells by chemotherapy and radiation, but it is not known if this contributes to tumor cell death or helps tumor cells survive the anti-cancer therapy.

Autophagy is a cellular process that enables cells to turnover their contents, something that they do frequently. Autophagy is initiated in tumor cells by chemotherapy and radiation, but it is not known if this contributes to tumor cell death or helps tumor cells survive the anti-cancer therapy.

However, in a study using a mouse model of B cell lymphomas, researchers from the University of Pennsylvania have now shown that autophagy represents a survival mechanism for tumor cells treated with agents that initiate tumor cell death by a process known as apoptosis.

In the study, which appears online on January 18 in advance of publication in the February print issue of the Journal of Clinical Investigation, Craig Thompson and colleagues show that in a tumor in which apoptosis was induced by activation of p53 expression, autophagy was observed only in tumor cells not undergoing apoptosis.

If mice were unable to initiate autophagy, increased numbers of tumor cells undergoing apoptosis were detected. Furthermore, if these mice were treated with the chemotherapeutic agent cyclophosphamide, tumor cell apoptosis and tumor regression was increased and tumor recurrence was substantially delayed.

This study has clinical implications as it indicates that adjunct treatment with inhibitors of autophagy might increase the efficacy of apoptosis-inducing chemotherapeutics in human patients with cancer.

Reference: Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma (https://www.the-jci.org/article.php?id=28833)


Story Source:

The above story is based on materials provided by Journal Of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Clinical Investigation. "Tumor Cells Evade Death Through Autophagy." ScienceDaily. ScienceDaily, 22 January 2007. <www.sciencedaily.com/releases/2007/01/070118181935.htm>.
Journal Of Clinical Investigation. (2007, January 22). Tumor Cells Evade Death Through Autophagy. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2007/01/070118181935.htm
Journal Of Clinical Investigation. "Tumor Cells Evade Death Through Autophagy." ScienceDaily. www.sciencedaily.com/releases/2007/01/070118181935.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins