Featured Research

from universities, journals, and other organizations

Drug Blocks Lethal Motor-neuron Disease In Mice

Date:
February 24, 2007
Source:
Journal of Clinical Investigation
Summary:
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations in the gene SMN1 that prevent it producing the protein SMN. New research shows that in a lethal mouse model of SMA the drug trichostatin A (TSA), which is a hydroxamic acid HDAC inhibitor, can improve survival and attenuate disease, indicating that hydroxamic acid HDAC inhibitors might be potential therapeutics for the treatment of individuals with SMA.

Spinal muscular atrophy (SMA) is an inherited motor-neuron disease that, in its most severe form, leads to death before 2 years of age and for which there is no treatment. It is caused by mutations in the gene SMN1 that prevent SMN1 producing the protein SMN. A second gene, SMN2, can also produce SMN, but it is much less efficient than SMN1 at doing so. Developing ways to increase SMN production by SMN2 are therefore of potential therapeutic interest.

Related Articles


In a study that appears online on February 22 in advance of publication in the March print issue of the Journal of Clinical Investigation, Charlotte Sumner and colleagues from the NIH show that in a mouse model of SMA a drug known as trichostatin A (TSA) can increase the amount of SMN2 produced SMN in both neural tissues and muscles (the tissues that are affected in humans with SMA).

Importantly, daily administration of TSA (which is a hydroxamic acid HDAC inhibitor) to mice already showing signs of SMA-like disease improved their chances of survival and attenuated their disease symptoms.

This study therefore provides support for the idea that hydroxamic acid HDAC inhibitors should be developed for the treatment of individuals with SMA.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Drug Blocks Lethal Motor-neuron Disease In Mice." ScienceDaily. ScienceDaily, 24 February 2007. <www.sciencedaily.com/releases/2007/02/070222181243.htm>.
Journal of Clinical Investigation. (2007, February 24). Drug Blocks Lethal Motor-neuron Disease In Mice. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/02/070222181243.htm
Journal of Clinical Investigation. "Drug Blocks Lethal Motor-neuron Disease In Mice." ScienceDaily. www.sciencedaily.com/releases/2007/02/070222181243.htm (accessed October 24, 2014).

Share This



More Plants & Animals News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Weird-Looking Dinosaur Solves 50-Year-Old Mystery

Weird-Looking Dinosaur Solves 50-Year-Old Mystery

Newsy (Oct. 23, 2014) You've probably seen some weird-looking dinosaurs, but have you ever seen one this weird? It's worth a look. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins