Featured Research

from universities, journals, and other organizations

Patients With Type 1 Diabetes Don't Wake In Response To Hypoglycemia

Date:
February 28, 2007
Source:
Public Library of Science
Summary:
A study of 16 patients with type 1 diabetes mellitus (T1DM) and 16 normal individuals shows that only one of the 16 T1DM patients, as compared to ten healthy control participants, awakened upon hypoglycemia.

Physiological responses to insulin-induced hypoglycemia during human sleep. (Credit: Photo by Natalie Kriwy)
Credit: Photo by Natalie Kriwy

A study of 16 patients with type 1 diabetes mellitus (T1DM) and 16 normal individuals shows that only one of the 16 T1DM patients, as compared to ten healthy control participants, awakened upon hypoglycemia.

Bernd Schultes and colleagues from the University of Lubeck induced hypoglycemia with insulin under controlled conditions and then assessed sleep with polysomography. A fall in plasma glucose to 2.2 mmol/l, which provoked an awakening response in most healthy control participants, did not provoke awakening in most patients with T1DM. On a control night, with no hypoglycemia, none of the participants from either group awakened. The researchers also looked at hormonal changes and found that in all the study participants from both groups who woke up, and in five of the study participants who did not awaken (three T1DM patients and two healthy control participants), plasma epinephrine concentration increased with hypoglycemia by at least 100%. In all participants who awakened increases in epinephrine always started before polysomnographic signs of wakefulness.

These results suggest that the awakening response to hypoglycemia is impaired in T1DM patients. It appears that awakening forms part of a central nervous system response to hypoglycemia and that failure to awaken increases the risk for T1DM patients to suffer prolonged hypoglycemia.

In a related perspective Harry Shamoon and Ilan Gabriely, from the Albert Einstein College of Medicine, discuss the paper further and conclude although further work is need to investigate the precise mechanisms involved, it "strongly supports and further advances the current notion of T1DM susceptibility to nocturnal hypoglycemia"

Citation: Schultes B, Jauch-Chara K, Gais S, Hallschmid M, Reiprich E, et al. (2007) Defective awakening response to nocturnal hypoglycemia in patients with type 1 diabetes mellitus. PLoS Med 4(2): e69. (http://dx.doi.org/10.1371/journal.pmed.0040069)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Patients With Type 1 Diabetes Don't Wake In Response To Hypoglycemia." ScienceDaily. ScienceDaily, 28 February 2007. <www.sciencedaily.com/releases/2007/02/070227105837.htm>.
Public Library of Science. (2007, February 28). Patients With Type 1 Diabetes Don't Wake In Response To Hypoglycemia. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2007/02/070227105837.htm
Public Library of Science. "Patients With Type 1 Diabetes Don't Wake In Response To Hypoglycemia." ScienceDaily. www.sciencedaily.com/releases/2007/02/070227105837.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins