Featured Research

from universities, journals, and other organizations

Researcher Finds New Way To Treat Devastating Fungal Infections

Date:
March 5, 2007
Source:
University of British Columbia
Summary:
Devastating blood-borne fungal infections that can be lethal for HIV/AIDS, cancer and organ transplant patients may be treated more successfully, thanks to a new drug delivery method developed by researchers at the University of British Columbia in Vancouver.

Devastating blood-borne fungal infections that can be lethal for HIV/AIDS, cancer, and organ transplant patients may be treated more successfully, thanks to a new drug delivery method developed by researchers at the University of British Columbia in Vancouver.

Related Articles


Pharmaceutical Sciences Prof. Kishor M. Wasan has created a liquid preparation that incorporates drug molecules in fat (lipid-based formulation) so that Amphotericin B, a potent anti-fungal agent, can be taken by mouth with minimal side effects. The agent, used for about 50 years, is currently administered intravenously and has significant toxic side effects, notably severe kidney toxicity as well as serious tissue damage at the intravenous injection site.

Wasan and his research team have discovered that the oral preparation triggers a different molecular interaction than intravenous delivery. The lipid-based system attacks fungal cells only while inhibiting the drug's interaction with kidney cells -- boosting effectiveness and dramatically reducing toxicity.

The research findings will be presented today at a meeting sponsored by the American Association of Pharmaceutical Scientists in Washington, D.C. Findings will be published in July 2007 in Drug Development and Industrial Pharmacy.

Because the oral form of the drug is easier to administer and cheaper than intravenous delivery, Wasan predicts that more patients -- especially those in underserved areas and developing countries -- would have access to the medicine. He notes that Amphotericin B is also used to treat Leishmaniasis, a parasitic disease that affects an estimated two million people worldwide according to the Centers for Disease Control and Prevention (CDCP) in the U.S.

"This research was triggered by clinicians needing a way to kill these fungal infections without risking the patient's kidney," says Wasan, who is a Distinguished University Scholar and a Canadian Institutes of Health Research Chair in Drug Development. "Despite antifungal agents, treating these infections is difficult and challenges researchers to find better outcomes for the patient."

Wasan tested the drug delivery method, in animal models, against two fungal infections seen in their most severe forms in people with suppressed immune systems, such as surgical patients and those with chronic illness.

He treated Candida albicans, often seen as esophageal candidiasis, an infection prevalent in HIV/AIDS and cancer patients receiving chemotherapy, and aspergillosis, an infection caused by aspergillus fumigatis, a family of common moulds that can cause symptoms ranging from cough to brain damage. The oral formulation proved effective and minimally toxic against both infections.

A clinical study of the drug delivery system, involving 50-100 patients, is planned for later this year. A form of invasive candidiasis called candidemia is the fourth most common bloodstream infection among hospitalized patients in the U.S. A survey conducted at CDCP found that candidemia occurs in eight of every 100,000 persons per year. Persons at high risk include low-birth-weight babies and surgical patients.

Incidence of invasive aspergillosis was five-10 per 1,000, according to an analysis of medical records of 35,232 HIV-infected patients who attended outpatient clinics in 10 U.S. cities between 1990 and 1998, according to Health Canada.

Research funding for this project has been provided by the Canadian Institutes of Health Research, Canada's major agency responsible for funding health research. Composed of 13 Institutes, CIHR provides leadership and support to more than 10,000 health researchers and trainees across Canada.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Cite This Page:

University of British Columbia. "Researcher Finds New Way To Treat Devastating Fungal Infections." ScienceDaily. ScienceDaily, 5 March 2007. <www.sciencedaily.com/releases/2007/03/070305141208.htm>.
University of British Columbia. (2007, March 5). Researcher Finds New Way To Treat Devastating Fungal Infections. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2007/03/070305141208.htm
University of British Columbia. "Researcher Finds New Way To Treat Devastating Fungal Infections." ScienceDaily. www.sciencedaily.com/releases/2007/03/070305141208.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins