Featured Research

from universities, journals, and other organizations

Why Is Long-term Therapy Required To Cure Tuberculosis?

Date:
March 21, 2007
Source:
Public Library of Science
Summary:
Understanding why other bacteria become resistant to antibiotics could hold the key to understanding why TB takes so long to cure, say researchers in a policy paper in PLoS Medicine.

Global tuberculosis mortality by region, 2004 Estimated 1.7 million deaths worldwide.
Credit: Data from the WHO, figure by Lynn E. Connolly

Understanding why other bacteria become resistant to antibiotics could hold the key to understanding why TB takes so long to cure, say researchers in a policy paper in PLoS Medicine.

Patients with TB typically have to take 4 antibiotics for 2 months and then continue 2 of these antibiotics for an additional 4 months. Why is such long treatment needed?

Lalita Ramakrishnan (University of Washington) and colleagues say that traditionally the answer was thought to lie in the fact that the tuberculosis microbe achieves a TB-specific "dormant" or non-replicating state in an infected person. Because virtually all types of antibiotics act only on replicating bacteria, the dormant state of TB is thought to render it resistant to treatment.

But the authors now challenge this traditional view. In the light of data on treating human TB and other bacterial infections, they suggest that the non-replicating state is not TB-specific and that the number of non-replicating bacteria correlates with total bacterial burden rather than TB-specific pathology.

"This correlation between bacterial burden and time to cure is not unique to TB, as it has been found in other bacterial infections, both acute and chronic," they say.

Understanding and countering the ways in which bacteria in general (rather than TB specifically) become resistant to antibiotics, say Ramakrishnan and colleagues, "may hold the key to reducing the duration of treatment of all recalcitrant bacterial infections, including TB."

Citation: Connolly LE, Edelstein PH, Ramakrishnan L (2007) Why is long-term therapy required to cure tuberculosis? PLoS Med 4(3): e120.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Why Is Long-term Therapy Required To Cure Tuberculosis?." ScienceDaily. ScienceDaily, 21 March 2007. <www.sciencedaily.com/releases/2007/03/070320095848.htm>.
Public Library of Science. (2007, March 21). Why Is Long-term Therapy Required To Cure Tuberculosis?. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2007/03/070320095848.htm
Public Library of Science. "Why Is Long-term Therapy Required To Cure Tuberculosis?." ScienceDaily. www.sciencedaily.com/releases/2007/03/070320095848.htm (accessed September 23, 2014).

Share This



More Plants & Animals News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cat Lovers Flock to Los Angeles

Cat Lovers Flock to Los Angeles

AFP (Sep. 22, 2014) The best funny internet cat videos are honoured at LA's Feline Film Festival. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
Washed-Up 'Alien Hairballs' Are Actually Algae

Washed-Up 'Alien Hairballs' Are Actually Algae

Newsy (Sep. 22, 2014) Green balls of algae washed up on Sydney, Australia's Dee Why Beach. Video provided by Newsy
Powered by NewsLook.com
Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins