Featured Research

from universities, journals, and other organizations

Food Cue-related Brain Activity Linked To Obesity?

Date:
April 28, 2007
Source:
BioMed Central
Summary:
A unique pattern of gene expression observed in rats may be linked to a conditioned desire for food and excessive food intake, a recently published article suggests.

A unique pattern of gene expression observed in rats may be linked to a conditioned desire for food and excessive food intake, an article published in BMC Biology suggests.

Related Articles


It's well known that food-associated cues, such as advertising, can influence food intake. But the underlying neurobiology is far from clear. Craig A. Schiltz and colleagues from the University of Wisconsin Madison School of Medicine and Public Health, USA, created an experimental set up that allowed them to study patterns of gene expression linked to this motivational state - rats conditioned to expect a chocolate-flavoured treat in a particular environment, were subsequently denied their reward.

The research, conducted in the laboratory of Ann E. Kelly showed that expression of a handful of immediate early genes was increased in cortical, striatal, thalamic and hypothalamic brain regions. Food-related cues triggered dramatic changes in the functional connectivity of circuits involved in adaptive behaviour. For example, increased connectivity was seen between the cortex and two other regions - the amygdala and the striatum. Within the latter, there was a shift in activity from the outer shell to the inner core of the nucleus accumbens and an increased expression of the opioid-encoding proenkephalin gene.

Taken together, these results suggest that food-associated cues have a powerful influence on neuronal activity and gene expression in brain areas mediating complicated functions such as cognition and emotion, and more basic abilities such as arousal and energy balance. The pattern of activation differs from that elicited by neutral cues, and may well contribute to a conditioned motivational state that can lead to excessive food intake.

Article:  Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression, Craig A Schiltz, Quentin Z Bremer, Charles F Landry and Ann E Kelley,  BMC Biology


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Food Cue-related Brain Activity Linked To Obesity?." ScienceDaily. ScienceDaily, 28 April 2007. <www.sciencedaily.com/releases/2007/04/070427072312.htm>.
BioMed Central. (2007, April 28). Food Cue-related Brain Activity Linked To Obesity?. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2007/04/070427072312.htm
BioMed Central. "Food Cue-related Brain Activity Linked To Obesity?." ScienceDaily. www.sciencedaily.com/releases/2007/04/070427072312.htm (accessed November 29, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins