Featured Research

from universities, journals, and other organizations

New Link Between Down Syndrome And Alzheimer's Disease

Date:
May 7, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Scientists have shown that a protein involved in cholesterol metabolism may cause the accelerated onset of Alzheimer's Disease in individuals affected with Down Syndrome.

Scientists have shown that a protein involved in cholesterol metabolism may cause the accelerated onset of Alzheimer's Disease in individuals affected with Down Syndrome.

People with Down Syndrome -- a genetic disorder due to the presence of an extra chromosome 21 -- develop Alzheimer's disease (AD) earlier (mid- to late 30s) than the general population (mid- to late 70s). To understand why, scientists have studied genes from chromosome 21 that are also involved in AD. One of those genes has already been found: It produces a protein called amyloid precursor protein (APP) that helps create protein clusters that are the hallmark of AD.

Cheryl L. Wellington and colleagues have found another gene on chromosome 21 that produces a protein that regulates the amount of cholesterol present in a cell. The scientists showed that this protein influences the distribution and processing of APP and that it is present at high levels in the brains of Down Syndrome individuals. The new discovery may provide new ways to halt AD symptoms early in these individuals.

Article: "The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein" by Gavin H. Tansley, Braydon L. Burgess, Matt T. Bryan, Yuan Su, Veronica Hirsch-Reinshagen, Jonathan Pearce, Jeniffer Y Chan, Anna Wilkinson, Jeanette Evans, Kathryn E. Naus, Sean McIsaac, Kelley Bromley, Weihong Song, Hsui-Chiung Yang, Nan Wang, Ronald B. DeMattos, and Cheryl L. Wellington


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "New Link Between Down Syndrome And Alzheimer's Disease." ScienceDaily. ScienceDaily, 7 May 2007. <www.sciencedaily.com/releases/2007/05/070504143134.htm>.
American Society for Biochemistry and Molecular Biology. (2007, May 7). New Link Between Down Syndrome And Alzheimer's Disease. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2007/05/070504143134.htm
American Society for Biochemistry and Molecular Biology. "New Link Between Down Syndrome And Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2007/05/070504143134.htm (accessed October 2, 2014).

Share This



More Mind & Brain News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins