Featured Research

from universities, journals, and other organizations

Bone Marrow Stem Cells May Cure Eye Disease

Date:
May 13, 2007
Source:
University of Cincinnati
Summary:
Adult bone marrow stem cells may help cure certain genetic eye diseases, according to new medical research. Scientists have completed a study using mice which showed that bone marrow stem cells can switch roles and produce keratocan, a natural protein involved in the growth of the cornea--the transparent, outer layer of the eyeball. This ability of marrow cells to "differentiate" into keratocan-producing cells might provide a means for treating abnormal corneal cell growth in people.

The green in this diagram shows bone marrow stem cells that have been injected into the eye and have taken on the properties of corneal cellls. After being injected, the stem cells begin expressing cornea-specific proteins. This technology could one day help cure genetic eye diseases.
Credit: Image courtesy of University of Cincinnati

Adult bone marrow stem cells may help cure certain genetic eye diseases, according to UC researchers.

Scientists have completed a study using mice which showed that bone marrow stem cells can switch roles and produce keratocan, a natural protein involved in the growth of the cornea—the transparent, outer layer of the eyeball. This ability of marrow cells to “differentiate” into keratocan-producing cells might provide a means for treating abnormal corneal cell growth in people.

Winston Whei-Yang Kao, PhD, professor of ophthalmology, and Hongshan Liu, PhD, research scientist in the department of ophthalmology, will present their findings at the annual meeting of the Association for Research in Vision and Ophthalmology being held in Ft. Lauderdale, Fla., May 9 and10.

In the laboratory, the researchers induced corneal abnormalities that mimicked genetic eye mutations and then injected bone marrow stem cells into the corneas to see if they altered the mutations.

The study showed that after only one week, the abnormal corneas of animal models injected with bone marrow stem cells began to change shape and heal.“We found that bone marrow stem cells can contribute to the formation of connective tissues,” Kao said. “If we can change the function of non-corneal bone marrow stem cells by introducing them into human corneas, we can possibly repair the loss of visual sharpness caused by mutations.”

Kao and his coworkers are now planning a clinical trial. If the trial succeeds, Kao said, the procedure could help prevent blindness in future generations who suffer from genetic corneal diseases.

He added that cornea transplants have been successful to some degree but do not always eliminate the problem. ”When the donor cells disappear after a few years, the corneal disease often reoccurs,” he said. “However, if we can place the stem cells inside the cornea, they will repair the lost function of the mutated gene, and stem cells can presumably renew themselves and maintain effective treatment longer, if not forever.”

This study was funded by grants from the National Eye Institute, Research to Prevent Blindness, and Ohio Lions Eye Research Foundation.


Story Source:

The above story is based on materials provided by University of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati. "Bone Marrow Stem Cells May Cure Eye Disease." ScienceDaily. ScienceDaily, 13 May 2007. <www.sciencedaily.com/releases/2007/05/070510160859.htm>.
University of Cincinnati. (2007, May 13). Bone Marrow Stem Cells May Cure Eye Disease. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2007/05/070510160859.htm
University of Cincinnati. "Bone Marrow Stem Cells May Cure Eye Disease." ScienceDaily. www.sciencedaily.com/releases/2007/05/070510160859.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins