Featured Research

from universities, journals, and other organizations

Estrogen Levels, Sex Appear To Play Role In Lung Cancer Survival

Date:
June 5, 2007
Source:
Loyola University Health System
Summary:
Women with advanced lung cancer survive longer than men if they are age 60 or older, but researchers no found difference by sex among people younger than 60, a finding that may point the way to improved treatment, according to a study released at the American Society of Clinical Oncology (ASCO) annual meeting.

Women with advanced lung cancer survive longer than men if they are age 60 or older, but researchers no found difference by sex among people younger than 60, a finding that may point the way to improved treatment, according to a study released at the American Society of Clinical Oncology (ASCO) annual meeting.

Related Articles


“If estrogen levels interact with the efficacy of certain chemotherapy drugs or some other, as-yet-undefined factor, we can utilize this knowledge to design new therapies,” said lead study author Dr. Kathy S. Albain, director, thoracic oncology program at the Cardinal Bernardin Cancer Center, Loyola University Health System, Maywood, Ill.

Earlier studies suggested that women have better survival than men, possibly due to sex-related changes in drug metabolism based on estrogen levels.

“In the modern chemotherapy era, a detailed analysis of this issue had not been undertaken until now,” said Albain, professor, division of hematology/oncology, department of medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Ill.

For the study, the Southwest Oncology Group (SWOG) Committee on Special Populations and the SWOG Lung Committee analyzed data on 1,334 patients (36 percent women) from six consecutive Phase II or III advanced stage non-small cell lung carcinoma (NSCLC) clinical trials.

NSCLC is the most common form of lung cancer.

Results of the study, “Toxicity and survival by sex in patients with advanced non-small cell lung carcinoma (NSCLC) on modern Southwest Oncology Group (SWOG) trials,” shows that median one- and two-year survivals were significantly better for women compared with men. At one year, 35 percent of men survived; 13 percent survived at two years. In contrast, 46 percent of women survived one year and 19 percent survived two years.

“Women with advanced lung cancer lived longer than men,” said Albain. “However the survival benefit is for women age 60 or older. Age 60 is the cutoff point.

Albain reported the median survival for women age 60 or older was 11 months; for men it was 8 months.

Survival was similar by sex among people under age 60.

“Women had a 14 percent reduced risk of death,” said Albain, who also serves as vice president, National Lung Cancer Partnership, a national research advocacy organization.

Researchers found no major difference in patient and disease characteristics by sex, except for weight loss. In addition there was no difference in maximum toxicity grade, number of toxicities or specific toxicity types.

Albain also showed supporting data for the hypothesis that estrogen levels may be part of the explanation. “In women treated with standard chemotherapy on three studies, independent of our database, the survival improvement occurs in those with lower estrogen levels,” she said.

At Loyola, Albain is director, breast clinical research program; and co-director, the multidisciplinary breast oncology center at the Cardinal Bernardin Cancer Center.

Co-authors of the study include Joseph Unger, Southwest Oncology Group Statistical Center, Seattle; Carolyn C. Gotay, Ph.D, University of Hawaii Cancer Center, Honolulu; Dr. Angela M. Davies and Dr. David R. Gandara, University of California Davis Cancer Center, Sacramento; Dr. Martin Edelman, University of Maryland Greenebaum Cancer Center, Baltimore.

In addition, co-authors include Dr. Roy S. Herbst, M.D. Anderson Cancer Center, Houston; Dr. Karen Kelly, Kansas Masonic Cancer Research Institute, Kansas City, Kan.; Dr. Steve Williamson, University of Kansas Medical Center, Kansas City; and Dr. Antoinette J. Wozniak, Wayne State University Karmanos Cancer Institute, Detroit.


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Cite This Page:

Loyola University Health System. "Estrogen Levels, Sex Appear To Play Role In Lung Cancer Survival." ScienceDaily. ScienceDaily, 5 June 2007. <www.sciencedaily.com/releases/2007/06/070604222521.htm>.
Loyola University Health System. (2007, June 5). Estrogen Levels, Sex Appear To Play Role In Lung Cancer Survival. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2007/06/070604222521.htm
Loyola University Health System. "Estrogen Levels, Sex Appear To Play Role In Lung Cancer Survival." ScienceDaily. www.sciencedaily.com/releases/2007/06/070604222521.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins