Featured Research

from universities, journals, and other organizations

New 'Longboat Delivery System' Could Mean More Potent Anti-cancer Drugs

Date:
July 5, 2007
Source:
American Chemical Society
Summary:
Scientists are reporting development of carbon nanotubes as a "longboat delivery system" that shows potential for addressing shortcomings that have hindered development of more generally applicable platinum-based anticancer drugs. These include analogues of the widely used and extremely potent drugs cisplatin, carboplatin, and oxaliplatin.

Scientists are reporting development of carbon nanotubes as a “longboat delivery system” that shows potential for addressing shortcomings that have hindered development of more generally applicable platinum-based anticancer drugs. These include analogues of the widely used and extremely potent drugs cisplatin, carboplatin, and oxaliplatin. The report is scheduled for the July 11 issue of the Journal of the American Chemical Society, a weekly publication.

Related Articles


The Massachusetts Institute of Technology’s Stephen J. Lippard and Stanford University’s Hongjie Dai and colleagues note that efforts to produce such molecules have been hindered because the required form of platinum loses activity in the body and becomes ineffective before reaching the tumor.

Their solution was to develop a carbon nanotube delivery system, ultimately for shuttling platinum compounds safely through the body’s biochemical obstacle course and into the tumor. Once inside the tumor cell, the compounds convert from an inactive form into an active anti-cancer drug.

The chemistry involves attaching platinum compounds to single wall carbon nanotubes (SWNTs), one-atom thick sheets of graphite rolled up into a cylinder with a diameter about 50,000 times smaller than the width of a human hair. The SWNTs act as efficient transporters for the platinum warhead, carrying it to the tumor cell and then releasing the platinum as an active drug.

In one experiment with cultured cells, the SWNTs produced platinum levels inside the cells 6-8 times higher than those for the platinum unit administered in the traditional way. The longboat SWNTs have the potential to carry other passengers to and into the cancer cell, as demonstrated by the co- delivery of platinum and a fluorescent dye to the cancer cell, which in the future will include tumor-targeting components.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "New 'Longboat Delivery System' Could Mean More Potent Anti-cancer Drugs." ScienceDaily. ScienceDaily, 5 July 2007. <www.sciencedaily.com/releases/2007/07/070702150921.htm>.
American Chemical Society. (2007, July 5). New 'Longboat Delivery System' Could Mean More Potent Anti-cancer Drugs. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2007/07/070702150921.htm
American Chemical Society. "New 'Longboat Delivery System' Could Mean More Potent Anti-cancer Drugs." ScienceDaily. www.sciencedaily.com/releases/2007/07/070702150921.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins