Featured Research

from universities, journals, and other organizations

Narcoleptics Have A High Frequency Of REM Sleep Without Atonia

Date:
July 7, 2007
Source:
American Academy of Sleep Medicine
Summary:
Normal rapid eye movement (REM) sleep is characterized by tonic features, including cortical electroencephalogram (EEG) desynchronization and muscle atonia, as well as phasic events, including bursts of REM, phasic activities of both chin and limb electromyography (EMG), and cardiorespiratory variability. Persons with narcolepsy, however, have a high frequency of REM sleep without atonia and of elevated EMG phasic density, according to a recent study.

Normal rapid eye movement (REM) sleep is characterized by tonic features, including cortical electroencephalogram (EEG) desynchronization and muscle atonia, as well as phasic events, including bursts of REM, phasic activities of both chin and limb electromyography (EMG), and cardiorespiratory variability. Persons with narcolepsy, however, have a high frequency of REM sleep without atonia and of elevated EMG phasic density, according to a study published in the July 1st issue of the journal SLEEP.

The study, conducted by Jacques Montplaisir, MD, PhD, of the Sleep Disorders Center at the Universitι de Montrιal in Canada, focused on 16 patients with narcolepsy and cataplexy, who were matched for age and sex with 16 patients with "idiopathic" REM sleep behavior disorder (RBD) and with 16 normal controls.

In his research, Dr. Montplaisir discovered that higher percentages of REM sleep without atonia, phasic EMG activity and REM density were found in patients with narcolepsy than normal controls. In contrast, RBD patients had a higher percentage of REM sleep without atonia, but a lower REM density than patients with narcolepsy and normal controls.

Based on a threshold of 80 percent for percentage of REM sleep with atonia, 50 percent of narcoleptics and 87.5 percent of RBD patients had abnormal REM sleep muscle activity. A higher frequency of periodic limb movements during wake and during sleep in narcoleptic patients, compared to controls, was also noted.

"This study also shows several REM sleep motor dyscontrol similarities between narcolepsy and RBD, suggesting the possibility of a common neurobiological defect of motor inhibition during REM sleep," said Montplaisir. "However, behavioral manifestations in REM sleep seem to be less frequent and severe in narcolepsy than in 'idiopathic' RBD. These results also support the idea that a decreased hypocretinergic and/or dopaminergic abnormalities input to brainstem structures may contribute to dissociated sleep/wake states."

Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably during the day. It also includes features of dreaming that occur while awake. Other common symptoms include sleep paralysis, hallucinations and cataplexy.

About one out of every 2,000 people is known to have narcolepsy. There appears to be a genetic link to it.

Those who think they might have narcolepsy, or another sleep disorder, are urged to discuss their problem with their primary care physician, who will issue a referral to a sleep specialist.

Article: "REM Sleep Characteristics in Narcolepsy and REM Sleep Behavior Disorder"


Story Source:

The above story is based on materials provided by American Academy of Sleep Medicine. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Sleep Medicine. "Narcoleptics Have A High Frequency Of REM Sleep Without Atonia." ScienceDaily. ScienceDaily, 7 July 2007. <www.sciencedaily.com/releases/2007/07/070703171907.htm>.
American Academy of Sleep Medicine. (2007, July 7). Narcoleptics Have A High Frequency Of REM Sleep Without Atonia. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2007/07/070703171907.htm
American Academy of Sleep Medicine. "Narcoleptics Have A High Frequency Of REM Sleep Without Atonia." ScienceDaily. www.sciencedaily.com/releases/2007/07/070703171907.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) — Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) — Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) — Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins