Featured Research

from universities, journals, and other organizations

Narcoleptics Have A High Frequency Of REM Sleep Without Atonia

Date:
July 7, 2007
Source:
American Academy of Sleep Medicine
Summary:
Normal rapid eye movement (REM) sleep is characterized by tonic features, including cortical electroencephalogram (EEG) desynchronization and muscle atonia, as well as phasic events, including bursts of REM, phasic activities of both chin and limb electromyography (EMG), and cardiorespiratory variability. Persons with narcolepsy, however, have a high frequency of REM sleep without atonia and of elevated EMG phasic density, according to a recent study.

Normal rapid eye movement (REM) sleep is characterized by tonic features, including cortical electroencephalogram (EEG) desynchronization and muscle atonia, as well as phasic events, including bursts of REM, phasic activities of both chin and limb electromyography (EMG), and cardiorespiratory variability. Persons with narcolepsy, however, have a high frequency of REM sleep without atonia and of elevated EMG phasic density, according to a study published in the July 1st issue of the journal SLEEP.

Related Articles


The study, conducted by Jacques Montplaisir, MD, PhD, of the Sleep Disorders Center at the Université de Montréal in Canada, focused on 16 patients with narcolepsy and cataplexy, who were matched for age and sex with 16 patients with "idiopathic" REM sleep behavior disorder (RBD) and with 16 normal controls.

In his research, Dr. Montplaisir discovered that higher percentages of REM sleep without atonia, phasic EMG activity and REM density were found in patients with narcolepsy than normal controls. In contrast, RBD patients had a higher percentage of REM sleep without atonia, but a lower REM density than patients with narcolepsy and normal controls.

Based on a threshold of 80 percent for percentage of REM sleep with atonia, 50 percent of narcoleptics and 87.5 percent of RBD patients had abnormal REM sleep muscle activity. A higher frequency of periodic limb movements during wake and during sleep in narcoleptic patients, compared to controls, was also noted.

"This study also shows several REM sleep motor dyscontrol similarities between narcolepsy and RBD, suggesting the possibility of a common neurobiological defect of motor inhibition during REM sleep," said Montplaisir. "However, behavioral manifestations in REM sleep seem to be less frequent and severe in narcolepsy than in 'idiopathic' RBD. These results also support the idea that a decreased hypocretinergic and/or dopaminergic abnormalities input to brainstem structures may contribute to dissociated sleep/wake states."

Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably during the day. It also includes features of dreaming that occur while awake. Other common symptoms include sleep paralysis, hallucinations and cataplexy.

About one out of every 2,000 people is known to have narcolepsy. There appears to be a genetic link to it.

Those who think they might have narcolepsy, or another sleep disorder, are urged to discuss their problem with their primary care physician, who will issue a referral to a sleep specialist.

Article: "REM Sleep Characteristics in Narcolepsy and REM Sleep Behavior Disorder"


Story Source:

The above story is based on materials provided by American Academy of Sleep Medicine. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Sleep Medicine. "Narcoleptics Have A High Frequency Of REM Sleep Without Atonia." ScienceDaily. ScienceDaily, 7 July 2007. <www.sciencedaily.com/releases/2007/07/070703171907.htm>.
American Academy of Sleep Medicine. (2007, July 7). Narcoleptics Have A High Frequency Of REM Sleep Without Atonia. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2007/07/070703171907.htm
American Academy of Sleep Medicine. "Narcoleptics Have A High Frequency Of REM Sleep Without Atonia." ScienceDaily. www.sciencedaily.com/releases/2007/07/070703171907.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Diné Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins