Featured Research

from universities, journals, and other organizations

EPA1 In The Brain Regulates The Female Reproductive Cycle

Date:
July 15, 2007
Source:
Journal of Clinical Investigation
Summary:
The onset of puberty and maintenance of the female reproductive cycle are events controlled by neurons in the hypothalamus that secrete gonadotropin-releasing hormone (GnRH). How signaling to these neurons is controlled remains unclear.

The onset of puberty and maintenance of the female reproductive cycle are events controlled by neurons in the hypothalamus that secrete gonadotropin-releasing hormone (GnRH). How signaling to these neurons is controlled remains unclear.

Related Articles


In a study appearing online on July 12 in advance of publication in the August print issue of the Journal of Clinical Investigation, Sergio Ojeda and colleagues from Oregon Health & Science University report that the gene enhanced at puberty 1 (EPA1) acts as a regulator of the neuronal signaling that controls female reproductive function.

The authors found that EPA1 expression was selectively increased at puberty in the hypothalamus in monkeys, rats, and mice. They also showed that the protein product of EPA1 was expressed in neurons involved in the control of reproduction, and that EAP1 activated GnRH. The authors went on to show that inhibition of EPA1 expression in the rat hypothalamus delayed the onset of puberty and disrupted estrous in these animals.

The data suggest that EPA1 is an important regulator acting within the brain and contributes to the control of female reproductive function.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "EPA1 In The Brain Regulates The Female Reproductive Cycle." ScienceDaily. ScienceDaily, 15 July 2007. <www.sciencedaily.com/releases/2007/07/070713234025.htm>.
Journal of Clinical Investigation. (2007, July 15). EPA1 In The Brain Regulates The Female Reproductive Cycle. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2007/07/070713234025.htm
Journal of Clinical Investigation. "EPA1 In The Brain Regulates The Female Reproductive Cycle." ScienceDaily. www.sciencedaily.com/releases/2007/07/070713234025.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins