Featured Research

from universities, journals, and other organizations

Estrogen Plays An Important Role In Determining How Sensitive A Person Is To Pain

Date:
August 13, 2007
Source:
Karolinska Institutet
Summary:
Estrogen plays an important role in determining how sensitive a person is to pain, and the estrogen receptor known as ER-beta is particularly significant in this context. These are the conclusions of a recent study. "This may mark the beginning of the production of a new class of analgesic drugs", says one of the scientists.

Estrogen plays an important role in determining how sensitive a person is to pain, and the estrogen receptor known as ER-beta is particularly significant in this context. These are the conclusions of a study from the Swedish medical university Karolinska Institutet, published in PNAS.

"This may mark the beginning of the production of a new class of analgesic drugs", says Professor Jan-Åke Gustafsson, Department of Biosciences and Nutrition.

Earlier studies have shown that estrogen affects how we experience pain, but the mechanisms behind this have been unclear. Estrogen can bind to two different receptors, known as ER-alpha and ER-beta, and the new study describes results obtained concerning the expression of these two receptors in the spinal cord.

The results show that ER-beta plays an important role in the development of the part of the spinal cord that contains nerve fibres that carry information to the brain. These nerves are important in several functions, including determining how sensitive a person is to pain, and response to sensation in general. ER-beta is the dominant estrogen receptor during the development of the embryo. The researchers also showed that neuronal development occurs later in mice that lack ER-beta, and that ER-beta is important in the spinal cord of the adult animal for the survival of nerve cells and for the transmission of pain and sensation.

"These results are particularly interesting in the light of preliminary results from pre-clinical studies that suggest that substances that stimulate ER-beta can give pain relief", says Jan-Åke Gustafsson.

Publication: Estrogen receptor beta is essential for sprouting of nociceptive primary afferents and for morphogenesis and maintenance of the dorsal horn interneurons, Xiaotang Fan, Hyun-Jin Kim, Margaret Warner, Jan-Åke Gustafsson. PNAS, Online Early Edition, 6-10 August 2007


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Estrogen Plays An Important Role In Determining How Sensitive A Person Is To Pain." ScienceDaily. ScienceDaily, 13 August 2007. <www.sciencedaily.com/releases/2007/08/070812094428.htm>.
Karolinska Institutet. (2007, August 13). Estrogen Plays An Important Role In Determining How Sensitive A Person Is To Pain. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2007/08/070812094428.htm
Karolinska Institutet. "Estrogen Plays An Important Role In Determining How Sensitive A Person Is To Pain." ScienceDaily. www.sciencedaily.com/releases/2007/08/070812094428.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins