Featured Research

from universities, journals, and other organizations

Air Pollutants Linked Blood Clotting In Mice, Mechanism Identified

Date:
September 23, 2007
Source:
Journal of Clinical Investigation
Summary:
Air pollution is caused by any particulate matter, chemical or biological agent that changes the natural characteristics of the atmosphere. Exposure to particulate matter has been linked to an increased risk of heart problems, including increased risk of heart attack. A new study in mice has now identified a mechanism by which exposure to particulate matter leads to accelerated blood clotting and thrombosis, something that can precipitate heart attacks and stroke.

Air pollution is caused by any particulate matter, chemical, or biological agent that changes the natural characteristics of the atmosphere.

Related Articles


Exposure to particulate matter has been linked to an increased risk of heart problems, including increased risk of heart attack.

In a new study, Gφkhan Mutlu and colleagues at Northwestern University Feinberg School of Medicine, Chicago, have identified in mice a mechanism by which exposure to particulate matter leads to accelerated blood clotting and thrombosis, something that can precipitate heart attacks and stroke.

Mice exposed to particulate matter were shown to have decreased bleeding times, accelerated blood clotting, and accelerated formation of an arterial thrombus.

As these effects of exposure to particulate matter were not observed in mice lacking IL-6 or depleted of lung macrophages, the authors suggested that particulate matter triggers lung macrophages to produce IL-6 that then mediates altered blood clotting and enhanced thrombus formation.

This study provides evidence to suggest that targeting IL-6 might decrease the risk of heart problems caused by exposure to particulate matter.

Article: "Ambient particulate matter accelerates coagulation via an IL-6--dependent pathway"


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Air Pollutants Linked Blood Clotting In Mice, Mechanism Identified." ScienceDaily. ScienceDaily, 23 September 2007. <www.sciencedaily.com/releases/2007/09/070920175721.htm>.
Journal of Clinical Investigation. (2007, September 23). Air Pollutants Linked Blood Clotting In Mice, Mechanism Identified. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2007/09/070920175721.htm
Journal of Clinical Investigation. "Air Pollutants Linked Blood Clotting In Mice, Mechanism Identified." ScienceDaily. www.sciencedaily.com/releases/2007/09/070920175721.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins