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Noninvasive Prenatal Testing By Analyzing Mother's Blood

Date:
September 26, 2007
Source:
Journal of Clinical Investigation
Summary:
Currently, prenatal diagnosis of genetic diseases and genetic monitoring of fetal development require invasive procedures. New data has indicated that it might be possible to perform these processes noninvasively by analyzing fetal mRNAs in the blood of pregnant woman.

Currently, prenatal diagnosis of genetic diseases and genetic monitoring of fetal development require invasive procedures. New data generated by Jill Maron and colleagues, at Tufts -- New England Medical Center, Boston, has indicated that it might be possible to perform these processes non-invasively.

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In the study, it was shown that a common pattern of fetal mRNAs, the molecules that hold the "blueprints" for proteins, was detectable in the blood of pregnant women. After birth, these mRNAs were no longer detected or were detected at substantially lower levels.

These data have two important implications: first, the common pattern of fetal mRNAs found in the blood of the pregnant women could serve as a baseline to compare fetuses affected by various pathologic conditions; and second, monitoring specific fetal mRNAs in the blood of pregnant women could be used for prenatal diagnosis of genetic diseases.

Article:  Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


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Journal of Clinical Investigation. "Noninvasive Prenatal Testing By Analyzing Mother's Blood." ScienceDaily. ScienceDaily, 26 September 2007. <www.sciencedaily.com/releases/2007/09/070921130730.htm>.
Journal of Clinical Investigation. (2007, September 26). Noninvasive Prenatal Testing By Analyzing Mother's Blood. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2007/09/070921130730.htm
Journal of Clinical Investigation. "Noninvasive Prenatal Testing By Analyzing Mother's Blood." ScienceDaily. www.sciencedaily.com/releases/2007/09/070921130730.htm (accessed November 29, 2014).

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