Featured Research

from universities, journals, and other organizations

Test Gives Insight Into Prognosis In Patients With Plasma Cell Malignancies

Date:
October 27, 2007
Source:
Mayo Clinic
Summary:
A chromosome test called 'FISH' is better than conventional methods in identifying chromosomal genetic abnormalities associated with plasma cell malignancies, according to a new study. Plasma cell proliferative disorders, or PCPD, account for approximately 10 percent of all blood born cancers that range from the very slow-growing smoldering myeloma to a very aggressive plasma cell leukemia.

A new Mayo Clinic study due to be presented at the annual meeting of the American Society of Human Genetics in San Diego this week shows that a chromosome test called "FISH" is better than conventional methods in identifying chromosomal genetic abnormalities associated with plasma cell malignancies. This improved chromosomal analysis may help physicians better assess a patient's prognosis and likelihood to respond to a given treatment.

Related Articles


Plasma cell proliferative disorders, or PCPD, account for approximately 10 percent of all blood born cancers that range from the very slow-growing smoldering myeloma to a very aggressive plasma cell leukemia.

FISH, which stands for fluorescence in situ hybridization, detected chromosomal abnormalities in 67 percent of 1,548 patients with suspected PCPD. Conventional chromosomal analysis detected abnormalities in only 10 percent of the same patients. The FISH test is designed to detect genetic abnormalities in plasma cells whereas other conventional methods typically looks within any cell type that is present, says the lead author of the study, Rhett Ketterling, M.D., a Mayo Clinic pathologist and geneticist who specializes in chromosomes and chromosomal abnormalities.

"This test is a marked improvement over conventional chromosomal analysis and has become readily accepted into the diagnostic algorithm in patients with PCPD at Mayo Clinic and at other leading academic institutions," Dr. Ketterling says.

The test should be applied to patients diagnosed with PCPD, particularly multiple myeloma, to determine the presence of genetic abnormalities that could offer insight into prognosis, he states.

"Our results show that a targeted plasma-cell specific FISH analysis is an important method for detecting common genetic abnormalities typically seen in patients with multiple myeloma," Dr. Ketterling says.

The study will be presented by Ryan Knudson of the Mayo Clinic Cytogenetics Laboratory on Oct. 24.

The study is funded by Mayo Clinic.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Test Gives Insight Into Prognosis In Patients With Plasma Cell Malignancies." ScienceDaily. ScienceDaily, 27 October 2007. <www.sciencedaily.com/releases/2007/10/071025080901.htm>.
Mayo Clinic. (2007, October 27). Test Gives Insight Into Prognosis In Patients With Plasma Cell Malignancies. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2007/10/071025080901.htm
Mayo Clinic. "Test Gives Insight Into Prognosis In Patients With Plasma Cell Malignancies." ScienceDaily. www.sciencedaily.com/releases/2007/10/071025080901.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins