Featured Research

from universities, journals, and other organizations

Key Protein In Leptospirosis Bacterium Identified

Date:
November 1, 2007
Source:
Cornell University
Summary:
Researchers have located a protein they believe is responsible for leptospirosis, a bacterial disease transmitted from animals to humans that infects a half-million people and leads to the death of up to 100,000 annually. The finding may help scientists create a vaccine to protect against the illness.

An electron micrograph of the pathogen, Leptospira interrogans, which is the cause of leptospirosis. The strain shown in the photo was obtained from a patient with severe leptospirosis in Salvador.
Credit: Image courtesy of Cornell University

Researchers at Weill Cornell Medical College have located a protein they believe is responsible for leptospirosis, a bacterial disease transmitted from animals to humans that infects a half-million people and leads to the death of up to 100,000 annually. The finding may help scientists create a vaccine to protect against the illness.

The protein is on the surface of the bacterium Leptospira interrogans, which causes leptospirosis.

"The disease is a major public health problem in urban slums of developing countries, such as Brazil," says Albert Ko, contributing researcher in the study and physician-scientist from the Division of International Medicine and Infectious Disease at the medical college.

The study, published recently in the Public Library of Science: Pathogens, shows that when a gene producing a protein called Loa22 is disrupted, the bacterium is rendered nonfunctional and unable to produce disease in guinea pigs. When the gene was reintroduced, the bacteria strains regained their virulence and ability to cause leptospirosis and death in guinea pigs.

In humans, leptospirosis is characterized by high fever, severe headache, chills, muscle aches, vomiting and may lead to jaundice, red eyes, abdominal pain, diarrhea or a rash. If left untreated, patients may develop kidney damage, meningitis, liver failure and respiratory distress, according to the Centers for Disease Control. Infection with the Leptospira bacteria can cause a severe pulmonary hemorrhage, which is associated with death in more than 50 percent of the cases with this syndrome.

Leptospira interrogans is found in the urine of infected animals, putting people who work with or are around such animals as cattle, pigs, horses, dogs, rodents and wild animals at greatest risk for infection. In cities in developing countries, large epidemics of rat-borne leptospirosis occur each year during the rainy season.

The disease is diagnosed through blood and urine testing. Treatment includes a course of oral or intravenous antibiotics.

Ko is stationed at Oswaldo Cruz Foundation/Brazilian Ministry of Health in Salvador, Brazil, as coordinator of a collaborative research and training program of infectious diseases and urban poverty.

The research was done in collaboration with Mathieu Picardeau and colleagues at Institut Pasteur, Paris. The article's lead author, Paula Ristow, and co-authors Flαvia McBride and Claudio Figueira, are trainees in Weill Cornell's Global Infectious Disease Training Program.


Story Source:

The above story is based on materials provided by Cornell University. Note: Materials may be edited for content and length.


Cite This Page:

Cornell University. "Key Protein In Leptospirosis Bacterium Identified." ScienceDaily. ScienceDaily, 1 November 2007. <www.sciencedaily.com/releases/2007/10/071027174533.htm>.
Cornell University. (2007, November 1). Key Protein In Leptospirosis Bacterium Identified. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2007/10/071027174533.htm
Cornell University. "Key Protein In Leptospirosis Bacterium Identified." ScienceDaily. www.sciencedaily.com/releases/2007/10/071027174533.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) — A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) — The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) — After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) — Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins