Featured Research

from universities, journals, and other organizations

Intriguing Approach To Developing Treatments For Chagas Disease Found

Date:
November 4, 2007
Source:
Public Library of Science
Summary:
Mexican researchers highlight a novel approach to discovering drugs for Chagas disease in a new laboratory study. Chagas disease, caused by the parasite Trypanosoma cruzi, affects about 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease: the existing drugs have severe side effects, require long courses of treatment, and show variable effectiveness.

Mexican researchers highlight a novel approach to discovering drugs for Chagas disease in a laboratory study reported in PLoS Neglected Tropical Diseases.

Chagas disease, caused by the parasite Trypanosoma cruzi, affects about 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease: the existing drugs have severe side effects, require long courses of treatment, and show variable effectiveness.

In the new study, Armando Gómez-Puyou (Universidad Nacional Autonoma de Mexico, Mexico City) and colleagues report results of their search for molecules that could eliminate the parasite. Their work targets an enzyme in the parasite called triosephosphate isomerase.

One of the problems with identifying molecules that attack parasitic enzymes is that most of these enzymes have a counterpart in the human host--and so the molecule may also attack the human enzyme (causing side effects in humans). But triosephosphate isomerase, which has two subunits, holds promise as a possible target because the human form differs from the parasitic form. Armando Gómez-Puyou and colleagues found significance differences in the interface between the two subunits in triosephosphate isomerase from Homo sapiens and that from Trypanosoma cruzi. They therefore searched for molecules that could specifically disrupt this interface in the parasitic form of the enzyme but not the human form.

In their search, they discovered that dithiodianiline (DTDA) is far more effective at inactivating the parasitic form of the enzyme than the human form, and its detrimental effect is due to it perturbing the interface between the two subunits.

By targeting this interface, the researchers say, "it is possible to discover small molecules that selectively thwart the life of the parasite."

Citation: Olivares-Illana V, Rodríguez-Romero A, Becker I, Berzunza M, García J, et al. (2007) Perturbation of the Dimer Interface of Triosephosphate Isomerase and its Effect on Trypanosoma cruzi. PLoS Negl Trop Dis 1(1): e01. doi:10.1371/journal.pntd.0000001


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Intriguing Approach To Developing Treatments For Chagas Disease Found." ScienceDaily. ScienceDaily, 4 November 2007. <www.sciencedaily.com/releases/2007/10/071030220102.htm>.
Public Library of Science. (2007, November 4). Intriguing Approach To Developing Treatments For Chagas Disease Found. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2007/10/071030220102.htm
Public Library of Science. "Intriguing Approach To Developing Treatments For Chagas Disease Found." ScienceDaily. www.sciencedaily.com/releases/2007/10/071030220102.htm (accessed July 30, 2014).

Share This




More Plants & Animals News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

In Virginia, the Rise of a New Space Coast

In Virginia, the Rise of a New Space Coast

AP (July 30, 2014) — Every summer, tourists make the pilgrimage to Chincoteague Island, Va. to see wild ponies cross the Assateague Channel. But, it's the rockets sending to supplies to the International Space Station that are making this a year-round destination. (July 30) Video provided by AP
Powered by NewsLook.com
Rodents Rampant in Gardens Around Louvre

Rodents Rampant in Gardens Around Louvre

AP (July 29, 2014) — Food scraps and other items left on the grounds by picnickers brings unwelcome visitors to the grounds of the world famous and popular Louvre Museum in Paris. (July 29) Video provided by AP
Powered by NewsLook.com
Jane Goodall Warns Great Apes Face Extinction

Jane Goodall Warns Great Apes Face Extinction

AFP (July 29, 2014) — The world's great apes face extinction within decades, renowned chimpanzee expert Jane Goodall warned Tuesday in a call to arms to ensure man's closest relatives are not wiped out. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) — Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins