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Connection Between Startled Response And Schizophrenia

Date:
November 14, 2007
Source:
Public Library of Science
Summary:
The search for responsible genes for prepulse inhibition, a measure deemed to be a biological trait in schizophrenia, has exposed a gene encoding essential fatty acid-binding protein.

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.
Credit: Yoshikawa et al.

Schizophrenia is a debilitating psychiatric illness. Its cause is currently poorly understood, and there is no known cure. In a new study Akiko Watanabe and colleagues report the identification of a gene linked to the condition.

Of particular interest to the study of schizophrenia is the so-called "gating" mechanism in the brain. This mechanism organizes information that comes from the sense organs, and when it malfunctions, it is believed to be responsible for the characteristic symptoms of schizophrenia: delusions, hallucinations, and social withdrawal.

Watanabe and colleagues, working in both Japan and the US, studied a behavior known to indicate a faulty gating mechanism: prepulse inhibition (PPI). A loud noise should make any animal jump, unless the noise is preceded by a quieter noise, which acts as a warning. However, in some individuals with schizophrenia, PPI fails.

Even noises with a preceding quiet "warning" sound will cause a startle response. Watanabe et al. investigated PPI in over 1000 mice to identify genetic variation that might underlie differences in startle response. The search honed in on the gene Fabp7.

Fabp7 (fatty acid binding protein) is involved in brain development and mental signaling. Mice that had faulty PPI had greater amounts of Fabp7, and so did the brains of deceased human patients who had experienced schizophrenia.

The paper also offers some hope for the future. The authors suggest testing the benefit of altered diet during pregnancy for women with a high risk of having schizophrenic babies, as changes in the amount of Fabp7 may be linked to problems with lipid metabolism.

Citation: Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, et al. (2007) Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biol 5(11): e297. doi:10.1371/journal.pbio.0050297


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The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Connection Between Startled Response And Schizophrenia." ScienceDaily. ScienceDaily, 14 November 2007. <www.sciencedaily.com/releases/2007/11/071112201245.htm>.
Public Library of Science. (2007, November 14). Connection Between Startled Response And Schizophrenia. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2007/11/071112201245.htm
Public Library of Science. "Connection Between Startled Response And Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2007/11/071112201245.htm (accessed April 23, 2014).

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