Featured Research

from universities, journals, and other organizations

How Chikungunya Virus Has Spread To New Vectors And Locations

Date:
December 10, 2007
Source:
Public Library of Science
Summary:
Researchers have discovered how a key protein switch allows chikungunya virus to spread to new vectors. The study explains how the virus has increased its ability to infect and be transmitted by the Asian tiger mosquito, Aedes albopictus.

Researchers at the University of Texas Medical Branch have discovered how a key protein switch allows Chikungunya Virus (CHIKV) to spread to new vectors. The study explains how the virus has increased its ability to infect and be transmitted by the Asian tiger mosquito, Aedes albopictus.

CHIKV is an emerging arbovirus associated with several recent large-scale epidemics of arthritic disease. The virus has formerly been known to be carried primarily by the mosquito Aedes aegypti. However, a recent epidemic in the Indian Ocean islands suggested that something else was carrying the virus, as Ae. aegypti are not found there. In fact the relative Asian tiger mosquito, Ae. albopictus, was present. This prompted the team, led by Dr. Stephen Higgs, to look further into the virus.

In an earlier study it had been found that the epidemics on islands in the Indian Ocean were associated with a strain of CHIKV with a mutation in the envelope protein gene (E1-A226V). Therefore, the researchers investigated the role of the E1-A226V mutation on the fitness of CHIKV in both types of mosquitoes. The team infected mosquitoes with two genetically-engineered clones of the virus, one with the mutation and the other without.

The team found the mutant virus out-competed the other virus with respect to transmission by the tiger mosquito. This proved that EI-A226V is directly responsible for CHIKV adaptation to the Asian tiger mosquito, explaining why the virus was found in an area which lacks the typical vector mosquito.

The Asian tiger mosquito is present in many countries. Both mosquito species are currently present in the U.S. and the Asian tiger mosquito is spreading in Europe. The findings suggest that, especially with the global climate warming, CHIKV could expand to new geographic locations.

Journal citation: Tsetsarkin KA, Vanlandingham DL, McGee CE, Higgs S (2007) A single mutation in Chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog 3(12): e201. doi:10.1371/journal.ppat.0030201


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "How Chikungunya Virus Has Spread To New Vectors And Locations." ScienceDaily. ScienceDaily, 10 December 2007. <www.sciencedaily.com/releases/2007/12/071207091940.htm>.
Public Library of Science. (2007, December 10). How Chikungunya Virus Has Spread To New Vectors And Locations. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2007/12/071207091940.htm
Public Library of Science. "How Chikungunya Virus Has Spread To New Vectors And Locations." ScienceDaily. www.sciencedaily.com/releases/2007/12/071207091940.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins