Featured Research

from universities, journals, and other organizations

Mechanism For Regulation Of Growth And Differentiation Of Adult Muscle Stem Cells Is Revealed

Date:
December 10, 2007
Source:
Burnham Institute
Summary:
During muscle regeneration, a natural response to injury and disease, environmental cues cause adult muscle stem cells to shift from dormancy to actively building new muscle tissue. Scientists analyzed the mechanism by which certain cellular signaling cues cause epigenetic modifications when released within the regenerative microenvironment, thus controlling the expression of genes that regulate growth and differentiation of muscle stem cells that repair injured muscle.

During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue.

Although the signaling pathways controlling muscle regeneration are fairly well known, how these signals lead to altered chromatin structure remains undiscovered.

A group of scientists at the Burnham Institute for Medical Research in La Jolla, CA, analyzed the mechanism by which certain cellular signaling cues cause epigenetic modifications when released within the regenerative microenvironment, thus controlling the expression of genes that regulate growth and differentiation of muscle stem cells that repair injured muscle.

In a recent publication in Molecular Cell, the scientific group, led by Pier Lorenzo Puri, MD, Ph.D., shows how two signaling pathways, PI3K/AKT and p38, work together to assemble components of the protein complexes responsible for muscle-specific transcription, and how each pathway is responsible for a distinct step in the transcription process.

Additionally, the team was able to pharmacologically separate these two steps, showing that selective interference with either cascade leads to incomplete assembly of protein complexes, thus preventing muscle-specific gene expression.

The results point to possible pharmacological avenues for selective control of gene expression in adult muscle stem cells that may have therapeutic potential in regenerative medicine.


Story Source:

The above story is based on materials provided by Burnham Institute. Note: Materials may be edited for content and length.


Cite This Page:

Burnham Institute. "Mechanism For Regulation Of Growth And Differentiation Of Adult Muscle Stem Cells Is Revealed." ScienceDaily. ScienceDaily, 10 December 2007. <www.sciencedaily.com/releases/2007/12/071207150725.htm>.
Burnham Institute. (2007, December 10). Mechanism For Regulation Of Growth And Differentiation Of Adult Muscle Stem Cells Is Revealed. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2007/12/071207150725.htm
Burnham Institute. "Mechanism For Regulation Of Growth And Differentiation Of Adult Muscle Stem Cells Is Revealed." ScienceDaily. www.sciencedaily.com/releases/2007/12/071207150725.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins