Featured Research

from universities, journals, and other organizations

Predicting Growth Hormone Treatment Success

Date:
December 17, 2007
Source:
BioMed Central
Summary:
Growth hormone treatments work better on some children than on others, but judging which candidates will gain those vital inches in height is no simple task, according to new research. Now researchers have developed a new mathematical model which predicts the optimal dose of growth hormone to treat children who are abnormally short for a wide range of reasons.

Growth hormone treatments work better on some children than on others, but judging which candidates will gain those vital inches in height is no simple task. Now researchers have developed a new mathematical model which predicts the optimal dose of growth hormone to treat children who are abnormally short for a wide range of reasons. A new study describes a model that can be more widely applied than previous versions, with greater predictive accuracy.

Jovanna Dahlgren and colleagues at Gothenburg University in Sweden analysed data from 415 short prepubertal children who had undergone GH treatment to develop a model that predicts an individual's response. The team gathered data including the children's length and weight at birth, height before and during treatment and their parents' height. The model was then validated by applying it to a group of 112 different children. The model's accuracy was substantially improved by including data on blood levels of growth hormone and other growth-related hormones, such as insulin-like growth factors and leptin.

Dr Dahlgren states, "The models presented serve as a practical clinical tool for selecting children for successful growth hormone treatment ... and provide the highest prediction accuracy available."

Growth hormone treatments are expensive, involve daily injections, and are associated with the risk of overdose. To assess whether growth hormone treatment would be appropriate for a particular child, an accurate prediction of how much growth would result from the treatment is crucial. This new research will help clinicians determine the children most likely to benefit from treatment, and the most appropriate dose.

Journal reference: Jovanna Dahlgren, Berit Kristrom, Aimon Niklasson, Andreas FM Nierop, Sten Rosberg, Kerstin Albertsson-Wikland. Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age. BMC Medical Informatics and Decision Making 2007, 7:40 (12 December 2007) (http://www.biomedcentral.com/bmcmedinformdecismak/)


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Predicting Growth Hormone Treatment Success." ScienceDaily. ScienceDaily, 17 December 2007. <www.sciencedaily.com/releases/2007/12/071212201410.htm>.
BioMed Central. (2007, December 17). Predicting Growth Hormone Treatment Success. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2007/12/071212201410.htm
BioMed Central. "Predicting Growth Hormone Treatment Success." ScienceDaily. www.sciencedaily.com/releases/2007/12/071212201410.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins