Featured Research

from universities, journals, and other organizations

Cardiovascular Disease: New Ideas For Treatment Of Atherosclerosis

Date:
December 15, 2007
Source:
Journal of Clinical Investigation
Summary:
Atherosclerosis is an inflammatory disease of the arterial blood vessels enhanced by the presence of immune cells known as macrophages. Macrophages migrate to the cholesterol-rich atherosclerotic plaques that form in the blood vessels and are the central component of atherosclerotic disease. Phospholipase C (PLC) is a protein that has known importance in immune cell signaling, although no specific known function in atherosclerosis. But now, researchers have discovered that the beta-3 form of PLC plays an important role in encouraging macrophage survival within atherosclerotic plaques.

Atherosclerosis is an inflammatory disease of the arterial blood vessels enhanced by the presence of immune cells known as macrophages. Macrophages migrate to the cholesterol-rich atherosclerotic plaques that form in the blood vessels and are the central component of atherosclerotic disease.

Phospholipase C (PLC) is a protein that has known importance in immune cell signaling, although no specific known function in atherosclerosis.

But now, Dianqing Wu and colleagues from Yale University School of Medicine, New Haven, have discovered that the beta-3 form of PLC plays an important role in encouraging macrophage survival within atherosclerotic plaques.

The authors generated mice deficient in PLC-beta-3. Although macrophages from these mice retained many of their normal functions, they were hypersensitive to inducers of a form of cell death known as apoptosis. Mice deficient in the protein apoE are more susceptible to atherosclerosis than normal mice. In the study, mice deficient in both apoE and PLC-beta-3 proteins were shown to have fewer macrophages within their atherosclerotic plaques, more macrophage apoptosis within the plaques, and smaller atherosclerotic plaques compared to mice deficient in apoE alone.

Because only macrophages appeared to be effected by the PLC-beta-3 deficiency, and because the effect on these macrophages seemed to be limited to their sensitivity to apoptosis, the authors concluded that PLC-beta-3 might provide a new therapeutic target in the prevention of atherosclerosis.

Article: Phospholipase C beta-3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. Journal of Clinical Investigation. Dec 14, 2007.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Cardiovascular Disease: New Ideas For Treatment Of Atherosclerosis." ScienceDaily. ScienceDaily, 15 December 2007. <www.sciencedaily.com/releases/2007/12/071214200818.htm>.
Journal of Clinical Investigation. (2007, December 15). Cardiovascular Disease: New Ideas For Treatment Of Atherosclerosis. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2007/12/071214200818.htm
Journal of Clinical Investigation. "Cardiovascular Disease: New Ideas For Treatment Of Atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2007/12/071214200818.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins