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Crohn Disease: Gene Decreases Intestinal Inflammation

Date:
January 7, 2008
Source:
Journal of Clinical Investigation
Summary:
There are two major types of inflammatory bowel disease, Crohn disease and ulcerative colitis. Conflicting reports have indicated the soluble factor IL-22 can have both IBD promoting and IBD controlling effects. A new study has, however, now indicated that local delivery of the Il-22 gene ameliorates disease in a mouse model of UC, leading to the suggestion that individuals with UC might benefit from local delivery of the IL-22 gene to their intestines.

There are two major types of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Conflicting reports have indicated that the soluble factor IL-22 can have both IBD promoting and IBD controlling effects.

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But now, Atsushi Mizoguchi and colleagues at Massachusetts General Hospital, Boston, have established that IL-22 ameliorates disease in a mouse model of UC.

Expression of IL-22 is much higher in the intestines of individuals with CD than UC. To investigate the role of IL-22 in IBD, the authors used a new microinjection-based strategy to deliver the gene that makes IL-22 to the walls of the intestine of mice who suffer from an intestinal disease that models UC.

Delivery of the Il-22 gene ameliorated local intestinal inflammation through enhanced mucus production. Consistent with this, when the same strategy was used to deliver a gene that makes a protein that neutralizes IL-22, IL-22--binding protein, to the walls of the intestines of normal mice it enhanced chemical-induced intestinal inflammation.

The authors therefore suggest that individuals with UC might benefit from local delivery of the IL-22 gene to their intestines.

Journal article: IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. Journal of Clinical Investigation. January 3, 2008.


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


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Journal of Clinical Investigation. "Crohn Disease: Gene Decreases Intestinal Inflammation." ScienceDaily. ScienceDaily, 7 January 2008. <www.sciencedaily.com/releases/2008/01/080102222928.htm>.
Journal of Clinical Investigation. (2008, January 7). Crohn Disease: Gene Decreases Intestinal Inflammation. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2008/01/080102222928.htm
Journal of Clinical Investigation. "Crohn Disease: Gene Decreases Intestinal Inflammation." ScienceDaily. www.sciencedaily.com/releases/2008/01/080102222928.htm (accessed March 6, 2015).

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