Featured Research

from universities, journals, and other organizations

Breakthrough In Lowering Bad Cholesterol, Fatty Acid Levels Reported

Date:
January 12, 2008
Source:
University of Alberta
Summary:
Medical researchers have found a way to reduce the amount of bad cholesterol and fatty acids that end up in the blood from food the body metabolizes, a key discovery that could lead to new drugs to treat and reverse the effects of diabetes and heart disease related to obesity. Existing drugs called statins are used to lower cholesterol, but do not treat obesity or diabetes.

There is "heartening" news out of the University of Alberta for those who may have overindulged during the recent holidays.

U of A medical researchers have found a way to reduce the amount of bad cholesterol and fatty acids that end up in the blood from food the body metabolizes, a key discovery that could lead to new drugs to treat and reverse the effects of Type 2 diabetes and heart disease related to obesity.

In a series of recently published articles,* Dr. Richard Lehner and his colleagues report they successfully decreased the level of LDL (low-density lipids) -- the so-called bad cholesterol -- in the blood of mice and hamsters by manipulating a particular enzyme.

It's well-known that eating too much fat and sugar and too little exercise will make you fat, and that obesity often leads to diabetes and heart disease. Lehner's group studied the mechanisms behind this.

"We established the proof of principle of how these metabolic pathways work," he says. "We discovered the activity of an enzyme that releases fatty acids from fat cells and the liver into the blood and how to inhibit this from happening."

Drugs called statins are used to lower LDL levels in patients, but do not treat obesity. What makes the U of A researchers' findings noteworthy is their discovery of how to inhibit LDL and triglycerides, which are another form of fat in the blood and a leading risk in obesity-related Type 2 diabetes as well as heart disease.

Lehner is director of the Group on Molecular and Cell Biology of Lipids in the U of A's Faculty of Medicine and Dentistry. The research is being supported by the Canadian Institutes of Health Research and the Heart and Stroke Foundation.

Lehner is also a senior scholar for the Alberta Heritage Foundation for Medical Research.

"There is a substantial pharmacological interest in the enzymes that control TG (triglycerides -- fatty acids) and cholesterol metabolism in tissues," he says.

This unique discovery is an important scientific breakthrough, but one that requires further testing, he notes.

He also notes that a pill would not be "a magic bullet." People still need to make the right lifestyle choices by exercising and eating properly, he says.

*Journal of Lipid Research (December 2007); Journal of Biological Chemistry (November 2007, March 2007)


Story Source:

The above story is based on materials provided by University of Alberta. Note: Materials may be edited for content and length.


Cite This Page:

University of Alberta. "Breakthrough In Lowering Bad Cholesterol, Fatty Acid Levels Reported." ScienceDaily. ScienceDaily, 12 January 2008. <www.sciencedaily.com/releases/2008/01/080110085145.htm>.
University of Alberta. (2008, January 12). Breakthrough In Lowering Bad Cholesterol, Fatty Acid Levels Reported. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2008/01/080110085145.htm
University of Alberta. "Breakthrough In Lowering Bad Cholesterol, Fatty Acid Levels Reported." ScienceDaily. www.sciencedaily.com/releases/2008/01/080110085145.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins