Featured Research

from universities, journals, and other organizations

How Antioxidant Therapy May Play A Role In The Treatment Of Type 2 Diabetes

Date:
January 11, 2008
Source:
Journal of Clinical Investigation
Summary:
The incidence of type 2 diabetes in Western society is on the rise, due largely to an increasing prevalence of obesity. Dysfunction of skeletal muscle mitochondria, the powerhouses of a cell, is associated with type 2 diabetes; however, whether this association is causal or consequential has not been understood.

The incidence of type 2 diabetes in Western society is on the rise, due largely to an increasing prevalence of obesity.

Related Articles


Dysfunction of skeletal muscle mitochondria, the powerhouses of a cell, is associated with type 2 diabetes; however, whether this association is causal or consequential has not been understood.

A new study by Jennifer Rieusset and her colleagues at INSERM U870, France, has shed light on this question and has provided evidence that alterations in mitochondrial function are the result, and not the cause, of insulin resistance (which usually precedes full-blown clinical type 2 diabetes) in mice.

Mice fed a high-fat, high-sucrose diet (HFHSD) developed insulin resistance and type 2 diabetes. The authors found that mitochondrial defects were present in diabetic, but not pre-diabetic glucose intolerant, mice.

The mitochondrial disruptions were subsequently shown to be the result of the generation of reactive oxygen species (ROS), highly reactive molecules implicated in a number of cellular disruptions. Indeed, ROS production coincided with mitochondrial dysfunction, and antioxidant treatment blocked the mitochondrial alterations in muscle cells.

The authors therefore concluded that treatment of diabetics with medications that either block ROS production or counteract their deleterious effects might improve the success of conventional therapies.

Journal article: Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. Journal Of Clinical Investigation. January 10, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "How Antioxidant Therapy May Play A Role In The Treatment Of Type 2 Diabetes." ScienceDaily. ScienceDaily, 11 January 2008. <www.sciencedaily.com/releases/2008/01/080110190902.htm>.
Journal of Clinical Investigation. (2008, January 11). How Antioxidant Therapy May Play A Role In The Treatment Of Type 2 Diabetes. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2008/01/080110190902.htm
Journal of Clinical Investigation. "How Antioxidant Therapy May Play A Role In The Treatment Of Type 2 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2008/01/080110190902.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins