Featured Research

from universities, journals, and other organizations

Seeing Is Believing: Visualizing Inflammation In Fat Tissue

Date:
January 25, 2008
Source:
Journal of Clinical Investigation
Summary:
Individuals who are obese are at increased risk of developing a combination of medical disorders associated with type 2 diabetes and heart disease known as the metabolic syndrome. Recent studies have suggested that adipose (fat) tissue obesity induces an inflammatory state that is crucial to the development of the metabolic syndrome.

Adipose tissue microcirculation visualized by in vivo molecular imaging. The erythrocyte, leukocyte and platelet cell dynamics can be visualized with high time and spatial resolutions in adipose tissue by in vivo molecular imaging method. Left: Capillary microcirculation visualized by FITC-dextran (green), and anti-CD41 (red). Right: Post capillary visualized by FITC-dextran. Scale bars represent 10 m.
Credit: Copyright Satoshi Nishimura, Department of Cardiovascular Medicine, the University of Tokyo

Individuals who are obese are at increased risk of developing a combination of medical disorders associated with type 2 diabetes and heart disease known as the metabolic syndrome. Recent studies have suggested that adipose (fat) tissue obesity induces an inflammatory state that is crucial to the development of the metabolic syndrome.

In a new study, Satoshi Nishimura, Ichiro Manabe, and colleagues at the University of Tokyo, Japan have developed a technique based on confocal laser microscopy to visualize cellular interactions within mouse adipose tissue in vivo with high spatiotemporal resolution. Changes indicative of inflammation were observed in the adipose tissue of both mice that were obese through genetic mutations and mice that were obese as a result of being fed a high-fat diet.

In addition, endothelial cells of the adipose tissue could be seen interacting with inflammatory cells known as macrophages, indicating a central role for interplay between these two cell types in the activation of inflammation within the adipose tissue.

The authors therefore concluded that adipose tissue obesity is an inflammatory disease and suggested that this technique might allow the efficacy of potential therapeutics for the treatment of individuals with diseases stemming from adipose tissue obesity to be evaluated in vivo in mice.

Journal article: In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. Journal of Clinical Investigation. Jan. 17, 2008


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Seeing Is Believing: Visualizing Inflammation In Fat Tissue." ScienceDaily. ScienceDaily, 25 January 2008. <www.sciencedaily.com/releases/2008/01/080118093619.htm>.
Journal of Clinical Investigation. (2008, January 25). Seeing Is Believing: Visualizing Inflammation In Fat Tissue. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2008/01/080118093619.htm
Journal of Clinical Investigation. "Seeing Is Believing: Visualizing Inflammation In Fat Tissue." ScienceDaily. www.sciencedaily.com/releases/2008/01/080118093619.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins