Featured Research

from universities, journals, and other organizations

A Taxing Issue: How Human T-lymphotropic Virus Can Cause Leukemia In Adults

Date:
February 1, 2008
Source:
BioMed Central
Summary:
Researchers have identified a potential new mechanism through which human T-lymphotropic virus type-1 causes leukemia in adults. The findings represent the first time that a reduction in histone protein levels has been linked to viral infection and the development of cancer.

Researchers have identified a potential new mechanism through which human T-lymphotropic virus type-1 (HTLV-1) causes leukemia in adults. The findings represent the first time that a reduction in histone protein levels has been linked to viral infection and the development of cancer.

HTLV-1 is a retrovirus that causes adult T-cell leukaemia/lymphoma (ATLL). A single protein made by the virus, Tax, is thought to be enough to trigger cancer development. Tax has a number of effects in the cell, including promoting inappropriate cell division, repressing DNA repair mechanisms and causing genomic instability. These effects are thought to combine and cause cancer, although the exact details of the process are unclear.

James Bogenberger and Paul Laybourn from Colorado State University, USA found that the levels of histone proteins and histone transcripts were lower in T-cell lines infected with HTLV-1 than in uninfected cell lines. They also showed that Tax could cause a drop in the levels of histone transcript in uninfected cells.

Histone proteins are required for the packaging of DNA in cell nuclei and are involved in many key processes associated with DNA, including transcription, repair and replication. The authors suggest that Tax uncouples cell division and replication-dependent histone gene expression, allowing cell division to continue while the levels of histone protein fall.

They write: "We suggest Tax repression of replication-dependent histone gene expression will result in reactivation of viral gene expression, deregulation of cellular gene expression and genomic instability. All of these effects may contribute to the development of adult T-cell leukemia/lymphoma. To our knowledge, this is the first example of a reduction of histone levels correlating with viral infection and cancer development."

Journal reference: Human T-Lymphotropic Virus Type 1 Protein Tax Reduces Histone Levels. James M Bogenberger and Paul J Laybourn. Retrovirology (in press) http://www.retrovirology.com/content/5/1/9


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "A Taxing Issue: How Human T-lymphotropic Virus Can Cause Leukemia In Adults." ScienceDaily. ScienceDaily, 1 February 2008. <www.sciencedaily.com/releases/2008/01/080131082244.htm>.
BioMed Central. (2008, February 1). A Taxing Issue: How Human T-lymphotropic Virus Can Cause Leukemia In Adults. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2008/01/080131082244.htm
BioMed Central. "A Taxing Issue: How Human T-lymphotropic Virus Can Cause Leukemia In Adults." ScienceDaily. www.sciencedaily.com/releases/2008/01/080131082244.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins