Featured Research

from universities, journals, and other organizations

Receptor Revealed That Turns On Genes After Consuming Unsaturated Fats

Date:
March 4, 2008
Source:
Wageningen University and Research Centre
Summary:
Scientists demonstrate the tremendous importance of dietary fat as a regulator of gene expression. Via a combination of several nutrigenomic tools they reveal that dietary unsaturated fatty acids govern a huge number of genes and do so almost entirely via a special receptor called PPARa.

Scientists from Wageningen University in the Netherlands demonstrate the tremendous importance of dietary fat as a regulator of gene expression. Via a combination of several nutrigenomic tools Linda Sanderson and her colleagues reveal that dietary unsaturated fatty acids govern a huge number of genes and do so almost entirely via a special receptor called PPARa.

PPARa, which stands for Peroxisome Proliferator Activated Receptor alpha, is a receptor that can be found in numerous tissues, including liver, heart and intestine. It reacts to certain drugs by turning on specific genes, yet can also respond to fatty acids and fatty acid look-a-likes. Activation of PPARa is known to lower levels of triglycerides in blood, providing a rationale for their use in patients suffering from altered blood lipid levels.

In their nutrigenomics study, the research team led by Linda Sanderson fed mice individual fatty acids in the form of synthetic triglycerides. Using a technique called microarray, which allows for monitoring the expression of thousands of genes simultaneously, they were able to determine exactly which genes are turned on in the mouse liver and which ones are turned off. The researchers found that the fatty acid DHA has the most significant impact and changes the expression of around 600 genes. DHA is found in fatty fish and fish oil and has been associated with numerous health benefits, including lowering of plasma triglycerides and decreasing blood clotting.

The most remarkable about the study is that the effects of unsaturated fatty acids are almost entirely lost in mice that lack the PPARa receptor.From the literature it is known that numerous receptors can supposedly bind fatty acids and turn on genes. Most of these receptors belong to the family of the so called 'nuclear hormone receptors', which includes receptors that bind steroid hormones and fat soluble vitamins. However, it was unknown how important they are in an actual living animal. The new data show that PPARa is by far the most important.

Many of the genes that are turned on by unsaturated fatty acids are involved in breaking down fatty acids to generate energy. This mechanism likely protects the liver cell from build-up of unsaturated fatty acids, which is harmful to the cell. It also likely accounts for the lowering of plasma triglycerides by fish oil.

Until now, all nutritional interventions with dietary fat in either mice or human subjects involved a mixture of fatty acids. For that reason, it has been very difficult to draw clear conclusions about the effects of individual fatty acids. The mixed nutritional/pharmacological intervention with synthetic triglycerides pursued by Sanderson and colleagues represents a creative and novel way to study the molecular effects of dietary fat. They expect that their approach will set a new standard for many future nutrigenomic studies.

This research was recently published in PloS One. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001681


Story Source:

The above story is based on materials provided by Wageningen University and Research Centre. Note: Materials may be edited for content and length.


Cite This Page:

Wageningen University and Research Centre. "Receptor Revealed That Turns On Genes After Consuming Unsaturated Fats." ScienceDaily. ScienceDaily, 4 March 2008. <www.sciencedaily.com/releases/2008/02/080229143151.htm>.
Wageningen University and Research Centre. (2008, March 4). Receptor Revealed That Turns On Genes After Consuming Unsaturated Fats. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/02/080229143151.htm
Wageningen University and Research Centre. "Receptor Revealed That Turns On Genes After Consuming Unsaturated Fats." ScienceDaily. www.sciencedaily.com/releases/2008/02/080229143151.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins