Featured Research

from universities, journals, and other organizations

Conditional Model of Parkinson's Disease Developed

Date:
March 7, 2008
Source:
Society for Neuroscience
Summary:
The pathological mediators of neurodegeneration in Parkinson's disease are unknown. One hypothesis postulates that neurodegeneration results from proteolytic stress due to accumulation and aggregation of misfolded or overexpressed proteins.

The pathological mediators of neurodegeneration in Parkinson's disease (PD) are unknown. One hypothesis postulates that neurodegeneration results from proteolytic stress due to accumulation and aggregation of misfolded or overexpressed proteins.

Related Articles


In support of this, mutations and duplications of the ±-synuclein gene are found in some PD families, and aggregates of ±-synuclein in cytoplasmic inclusions (Lewy bodies) are a hallmark of PD. 

Researchers report the development of transgenic mice that conditionally overexpress ±-synuclein.

The mice showed progressive loss of motor and cognitive function and some degeneration of hippocampal neurons and of dopaminergic neurons in the substantia nigra. Although cell death occurred in the substantia nigra, levels were below statistical significance, and most was not apoptotic as is seen in PD. ±-Synuclein aggregated but did not form Lewy bodies.

Interestingly, turning off ±-synuclein overexpression slowed the progression of motor dysfunction but did not alter cellular pathology.

Journal article:  Silke Nuber, Elisabeth Petrasch-Parwez, Beate Winner, Jürgen Winkler, Stephan von Hörsten, Thorsten Schmidt, Jana Boy, Melanie Kuhn, Huu P. Nguyen, Peter Teismann, Jörg B. Schulz, Manuela Neumann, Bernd J. Pichler, Gerald Reischl, Carsten Holzmann, Ina Schmitt, Antje Bornemann, Wilfried Kuhn, Frank Zimmermann, Antonio Servadio, and Olaf Riess. "Conditional Model of Parkinson's Disease" was published in the Journal of Neuroscience in March of 2008.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Conditional Model of Parkinson's Disease Developed." ScienceDaily. ScienceDaily, 7 March 2008. <www.sciencedaily.com/releases/2008/03/080304214427.htm>.
Society for Neuroscience. (2008, March 7). Conditional Model of Parkinson's Disease Developed. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/03/080304214427.htm
Society for Neuroscience. "Conditional Model of Parkinson's Disease Developed." ScienceDaily. www.sciencedaily.com/releases/2008/03/080304214427.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins