Featured Research

from universities, journals, and other organizations

Cellular Construction Methods Emulated at Nano-scale

Date:
March 6, 2008
Source:
Wiley-Blackwell
Summary:
Not only is our body made of individual organs, our cells themselves are made of tiny organelles, a variety of separate compartments that fulfill different tasks. Such functional, nanostructured systems would also be useful for technical applications, such as biosensors, self-repairing materials, optoelectronic components, or nanocapsules. However, it has not been possible to recreate structures with sufficient complexity in the lab. Researchers are now pursuing a new angle to produce functional nanostructured systems.

Researchers are now allowing surfactants and gelators to form aggregates.
Credit: Copyright Wiley-VCH

Not only is our body made of individual organs, our cells themselves are made of tiny organelles, a variety of separate compartments that fulfill different tasks. Such functional, nanostructured systems would also be useful for technical applications, such as biosensors, self-repairing materials, optoelectronic components, or nanocapsules. However, it has not been possible to recreate structures with sufficient complexity in the lab.

Researchers in the Netherlands, led by Jan van Esch at the Universities of Delft and Groningen as well as the BioMaDe Technology Foundation, are now pursuing a new angle. They are allowing surfactants and gelators to form aggregates. These aggregates coexist without interfering with each other and thus make versatile, highly complex structures with separate compartments.

Cells contain various components, such as channels, “motors”, structural frameworks (cytoskeleton), and “power plants” (mitochondria). In order for these to form, their building blocks, mainly proteins and lipids, must “recognize” each other and form the correct assembly by self-aggregation.

In addition, it is critical that compatible components do not separate into different phases: when proteins fold, the water-loving (hydrophilic) and water-repellent (hydrophobic) parts of the molecule stay far away from each other and aggregate with “like-minded” components. Biomembranes are formed when many small lipid molecules aggregate such that their hydrophobic “tails” face inward together and their hydrophilic “heads” point outward toward the aqueous medium.

The Dutch team imitated this concept by using two types of self-aggregating compounds: surfactants and gelators. Like the lipids in natural membranes, surfactants have a hydrophilic segment and a hydrophobic segment and aggregate into structures such as membrane-like double layers or vesicles (bubbles). To imitate the forces involved in protein folding—hydrogen-bridge bonds and hydrophobic interactions—the team used a disk-shaped gelator, in which hydrophobic and hydrophilic molecular components alternate in concentric rings. Just as for proteins, like attracts like. This causes the disks to stack together into columns, which forms long fibers, generating a three-dimensional network in the solution to make a gel.

The researchers allow their surfactants and gelators to aggregate together. In this process, the different components take no notice of each other. This independent formation of different supramolecular structures within a single system is called orthogonal self-aggregation. This results in the formation of novel, complex, compartmentalized architectures, for example, interpenetrating but independent networks or vesicle configurations that coexist with gel fibers.

Journal reference: Preparation of Nanostructures by Orthogonal Self-Assembly of Hydrogelators and Surfactants. Angewandte Chemie International Edition 2008, 47, 2063–2066. doi: 10.1002/anie.200704609


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Cellular Construction Methods Emulated at Nano-scale." ScienceDaily. ScienceDaily, 6 March 2008. <www.sciencedaily.com/releases/2008/03/080305105232.htm>.
Wiley-Blackwell. (2008, March 6). Cellular Construction Methods Emulated at Nano-scale. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2008/03/080305105232.htm
Wiley-Blackwell. "Cellular Construction Methods Emulated at Nano-scale." ScienceDaily. www.sciencedaily.com/releases/2008/03/080305105232.htm (accessed September 30, 2014).

Share This



More Plants & Animals News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

California University Designs Sustainable Winery

California University Designs Sustainable Winery

Reuters - US Online Video (Sep. 27, 2014) Amid California's worst drought in decades, scientists at UC Davis design a sustainable winery that includes a water recycling system. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
Argentina Worries Over Decline of Soybean Prices

Argentina Worries Over Decline of Soybean Prices

AFP (Sep. 27, 2014) The drop in price of soy on the international market is a cause for concern in Argentina, as soybean exports are a major source of income for Latin America's third largest economy. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Mama Bear, Cubs Hang out in California Backyard

Mama Bear, Cubs Hang out in California Backyard

Reuters - US Online Video (Sep. 27, 2014) A mama bear and her two cubs climb trees, wrestle and take naps in the backyard of a Monrovia, California home. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
'Crazy' Climate Forces Colombian Farmers to Adapt

'Crazy' Climate Forces Colombian Farmers to Adapt

AFP (Sep. 26, 2014) Once upon a time, farming was a blissfully low-tech business on Colombia's northern plains. Duration: 02:05 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins