Featured Research

from universities, journals, and other organizations

Low Micro-RNA Level Linked To High Gene Activity In AML

Date:
March 10, 2008
Source:
Ohio State University Medical Center
Summary:
A new study suggests that acute myeloid leukemia (AML) may occur in part because abnormally low levels of a particular microRNA result in the over-activity of two genes important to the disease. The research involved 85 patients with AML and gene mutations called NPM1, seen in about one-third of adult AML cases, and FLT3. The findings suggest new therapeutic targets for treating the disease and should improve the understanding of AML.

A new study suggests that a type of acute leukemia may occur in part because abnormally low levels of one small molecule result in the over-activity of genes important to the disease.

Related Articles


The research involved patients with acute myeloid leukemia (AML) and a gene mutation called NPM1, an alteration seen in about one-third of adult AML cases.

The findings suggest new therapeutic targets for treating the disease and should improve the understanding of AML, researchers say.

The study showed that a type of microRNA -- molecules important in controlling cell development and proliferation -- regulates two genes whose elevated activity has been linked to leukemia in humans and proven to cause leukemia in mice.

The two genes belong to the Hox family of genes, known to play a critical role in embryonic development and blood-cell development.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center, was published online Feb. 28 in the Proceedings of the National Academy of Sciences.

"We've shown that low levels of a microRNA called miR-204 are at least partly responsible for the high activity of these Hox genes," says first author Dr. Ramiro Garzon, an Ohio State cancer researcher.

"If this is verified, and if we can develop a drug to modulate this microRNA, it may provide a new therapeutic intervention for these patients."

For this study, the investigators examined microRNAs levels in leukemia cells from 85 patients. They also looked for mutations in two genes in the leukemic cells: NPM1 and FLT3 (pronounced "Flit-3").

The pattern of microRNA molecules present in the cells enabled the researchers to distinguish the 55 patients with mutated NPM1 genes from those with a normal gene.

Furthermore, 26 of the 85 patients had FLT3 mutations. These cases also had high levels of a microRNA called miR-155. Further experiments showed that while the high levels of miR-155 were closely associated with FLT3 mutations, they were independent of the mutation (i.e., it did not cause the high levels).

"This is significant," says Garzon, an assistant professor of internal medicine. "We already have drugs that target FLT3, but they are not effective by themselves. This finding suggests that if we develop a drug that targets miR-155, and combine it with a FLT3 inhibitor, we might achieve a more complete response in these patients."

Garzon and his colleagues are studying that possibility now.


Story Source:

The above story is based on materials provided by Ohio State University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University Medical Center. "Low Micro-RNA Level Linked To High Gene Activity In AML." ScienceDaily. ScienceDaily, 10 March 2008. <www.sciencedaily.com/releases/2008/03/080306190907.htm>.
Ohio State University Medical Center. (2008, March 10). Low Micro-RNA Level Linked To High Gene Activity In AML. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2008/03/080306190907.htm
Ohio State University Medical Center. "Low Micro-RNA Level Linked To High Gene Activity In AML." ScienceDaily. www.sciencedaily.com/releases/2008/03/080306190907.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins