Featured Research

from universities, journals, and other organizations

Gene And Activity Level Of HDL-associated Protein Linked To Risk Of Heart Disease

Date:
March 21, 2008
Source:
JAMA and Archives Journals
Summary:
The gene for the HDL-associated protein paraoxonase 1 appears to be associated with coronary artery disease and with the risk of developing adverse cardiac events, and variations in both the PON1 gene and its related enzyme activity may increase the risk for cardiovascular disease events.

The gene for the HDL-associated protein paraoxonase 1 (PON1) appears to be associated with coronary artery disease and with the risk of developing adverse cardiac events, and variations in both the PON1 gene and its related enzyme activity may increase the risk for cardiovascular disease events, according to a new study.

Related Articles


Despite evidence that PON1 prevents atherosclerosis in animals, a cardio-protective role in humans has not been established. Several studies have suggested that PON1 may have antioxidant and cardio-protective properties, according to background information in the article.

Dr. Stanley L. Hazen, M.D., Ph.D., of the Cleveland Clinic and colleagues conducted a study to examine the association between PON1 activity (such as anti-inflammatory and antioxidant activities) and if a PON1 gene variation (polymorphism) Q192R were associated with a higher rate of cardiovascular disease and major adverse cardiac events (heart attack, stroke or death). The study included 1,399 patients undergoing elective diagnostic coronary angiography between September 2002 and November 2003, and were followed-up until December 2006.

The researchers found that the incidence of major adverse cardiac events was significantly lower in participants in the highest PON1 activity quartile (7.3 percent for paraoxonase) compared with those in the lowest activity quartile (25.1 percent for paraoxonase).

The results also indicated that variations of the PON1 gene demonstrated significant dose-dependent associations with decreased levels of serum PON1 activity and increased levels of measures of oxidative stress (damage to cells and tissues from an imbalance between excess free radicals and not enough antioxidants), and that the PON1 Q192R polymorphism and serum PON1 activity were associated with both coronary artery disease and adverse cardiovascular events over the ensuing three year period after enrollment in the study.

"The current findings provide direct prospective evidence of an important mechanistic link between the PON1 gene and PON1 systemic activity measures with both multiple quantitative indices of oxidative stress and atherosclerotic heart disease development in humans. Paraoxonase 1 is [strongly] associated with HDL particles within the circulation and has been argued to promote some of the anti-inflammatory and antioxidant effects attributed to HDL. Thus, the present studies also provide further support for the concept that functional properties beyond the ability of HDL and its associated proteins to promote reverse cholesterol transport contribute to the overall ability of this lipoprotein to reduce or prevent development of atherosclerosis," the authors conclude.

Journal reference: JAMA. 2008;299[11]:1265-1276.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Gene And Activity Level Of HDL-associated Protein Linked To Risk Of Heart Disease." ScienceDaily. ScienceDaily, 21 March 2008. <www.sciencedaily.com/releases/2008/03/080318101006.htm>.
JAMA and Archives Journals. (2008, March 21). Gene And Activity Level Of HDL-associated Protein Linked To Risk Of Heart Disease. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2008/03/080318101006.htm
JAMA and Archives Journals. "Gene And Activity Level Of HDL-associated Protein Linked To Risk Of Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2008/03/080318101006.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins