Featured Research

from universities, journals, and other organizations

Infection With A Mutated HIV Strain Results In Better Survival

Date:
March 21, 2008
Source:
Public Library of Science
Summary:
Persons infected with a mutated HIV strain, transmitted from those who have the genetic advantages to control the virus, results in improved survival according to a recent study by South African researchers. The study looked for genetic mutations in the infecting virus in 24 newly infected people in Durban, South Africa.

Persons infected with a mutated HIV strain, transmitted from those who have the genetic advantages to control the virus, results in improved survival according to a recent study by South African researchers. The study looked for genetic mutations in the infecting virus in 24 newly infected people in Durban, South Africa.

The study was conducted by CAPRISA (the Centre for the AIDS Program of Research in South Africa) researchers at the Universities of Cape Town, KwaZulu-Natal, Western-Cape and the National Institute of Communicable Diseases in South Africa. According to Professor Salim Abdool Karim, Director of CAPRISA, "It is significant that the mutations to HIV which occur in a person with advantageous genes leads to a low viral load, even when the virus infects a new person who does not have these 'good' genes. Low viral load is a goal of several HIV vaccines as it means that these HIV infected people will be clinically well for longer and be less likely to spread the virus."

HLA genes affect the rate of disease progression in HIV-infected individuals, alerting the immune system to HIV's presence. HIV can evade the immune system by mutating into forms unrecognizable by the HLA. However, it is known that some people have versions of the HLA gene (for example HLA-B*57 and HLA-B*5801) that can only be evaded by the virus if it mutates to a form that has a reduced replication rate.

In this study the researchers identified two mutations, A146X and T242N, in the Gag sequences of acutely infected HLA-B*57/5801 negative women, that were associated with lower viral loads and higher CD4+ counts in these women up to a year post-infection. Both mutations have been previously identified as HLA-B*57/5801 immune evasion mutations and T242N has been shown to compromise viral replication capacity. This study now indicates time that HLA-B*57 or HLA-B*5801 negative people who are infected by such reproductively compromised viruses may also have better survival prospects.

"Disease progression is determined by a complex interplay between the host and the virus," says team leader Carolyn Williamson. "While the role of host genetics is well established, this study shows that genetic polymorphisms in the transmitted virus can offer survival advantage to a newly infected person."

The possibility that an interacting network of attenuating mutations may be responsible for better long-term survival could profoundly influence our understanding of the cause and development of HIV, Williamson says. This study has implications for HIV vaccine design and immunotherapeutics.

Journal reference: Chopera DR, Woodman Z, Mlisana K, Mlotshwa M, Martin DP, et al. (2008) Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog 4(3): e1000033. doi:10.1371/journal.ppat.1000033

The study was funded by the U.S. National Institutes for Health. Participants in this study were part of the CAPRISA 002 cohort investigating the role of viral and immunological factors in the early stages of HIV infections.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Infection With A Mutated HIV Strain Results In Better Survival." ScienceDaily. ScienceDaily, 21 March 2008. <www.sciencedaily.com/releases/2008/03/080320205213.htm>.
Public Library of Science. (2008, March 21). Infection With A Mutated HIV Strain Results In Better Survival. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2008/03/080320205213.htm
Public Library of Science. "Infection With A Mutated HIV Strain Results In Better Survival." ScienceDaily. www.sciencedaily.com/releases/2008/03/080320205213.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins