Featured Research

from universities, journals, and other organizations

New Method To Identify Mutated Genes In Human Diseases

Date:
March 30, 2008
Source:
Public Library of Science
Summary:
A new method may help the medical community to determine the genetic basis of many common diseases. Thousands of human diseases originate from mutations in one or more genes. Identification of mutated genes is a crucial first step towards understanding the molecular mechanisms at the origin of diseases and devising a treatment. In many cases, we do not know the identity of the affected gene, only a chromosomal region (typically containing hundred of genes) in which the mutation is located.

Researchers from the University of Turin, Italy and the University of Nijmegen, The Netherlands, have devised a new method that may help the medical community to determine the genetic basis of many common diseases.

Thousands of human diseases originate from mutations in one or more genes. Identification of mutated genes is a crucial first step towards understanding the molecular mechanisms at the origin of diseases and devising a treatment. In many cases, we do not know the identity of the affected gene, only a chromosomal region (typically containing hundred of genes) in which the mutation is located.

The research group, led by Ferdinando Di Cunto and Paolo Provero, analyzed gene expression data (patterns of gene activity in tissues and cell lines) from thousands of published experiments to identify genes showing patterns comparable to the ones of mutated genes in similar diseases. The study identified candidate genes for 81 diseases, including various forms of epilepsy and muscular dystrophy

As in all such analyses, the results must be verified experimentally. However, the task of understanding the molecular basis of many diseases could be significantly simplified by the results of this work.

Journal reference: Ala U, Piro RM, Grassi E, Damasco C, Silengo L, et al. (2008) Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis. PLoS Comput Biol 4(3): e1000043. doi:10.1371/journal.pcbi.1000043


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "New Method To Identify Mutated Genes In Human Diseases." ScienceDaily. ScienceDaily, 30 March 2008. <www.sciencedaily.com/releases/2008/03/080328070143.htm>.
Public Library of Science. (2008, March 30). New Method To Identify Mutated Genes In Human Diseases. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2008/03/080328070143.htm
Public Library of Science. "New Method To Identify Mutated Genes In Human Diseases." ScienceDaily. www.sciencedaily.com/releases/2008/03/080328070143.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins