Featured Research

from universities, journals, and other organizations

A Comprehensive Protein Map of a Stem Cell

Date:
April 7, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have successfully identified over 5,000 proteins that are present in embryonic stem cells, tripling the size of previous results and in the process creating the largest quantified protein map to date. Stem cells hold great potential in biology and medicine, but a host of questions lingers about how they operate and convert into other cells.

Researchers have successfully identified over 5,000 proteins that are present in embryonic stem cells, tripling the size of previous results and in the process creating the largest quantified protein map to date.

Stem cells hold great potential in biology and medicine, but a host of questions lingers about how they operate and convert into other cells. To help answer these questions, researchers have begun taking a 'big picture' approach, identifying all the proteins that are expressed in stem cells.

Currently, around 1700 proteins have been identified in stem cells. Now, using mass spectrometry and special "heavy" amino acids (made with carbon-13), Matthias Mann and colleagues quantified 5111 distinct mouse stem cell proteins. As expected, a good portion of these proteins are involved in rapid cell growth, but overall the proteome encompassed a broad range of cell functions.

While this study may help uncover new clues to stem cell biology, it does raise the bar on the complexity of these important cells, considering they express at least 25% of all known mouse proteins.

Journal reference: "SILAC-labeling and proteome quantitation of mouse embryonic stem cells to a depth of 5111 proteins" by Johannes Graumann, Nina Hubner, Jeong Beom Kim, Kinarm Ko, Markus Moser, Chanchal Kumar, Jόrgen Cox, Hans Schφler and Matthias Mann. Molecular & Cellular Proteomics. April 2008.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "A Comprehensive Protein Map of a Stem Cell." ScienceDaily. ScienceDaily, 7 April 2008. <www.sciencedaily.com/releases/2008/04/080404122202.htm>.
American Society for Biochemistry and Molecular Biology. (2008, April 7). A Comprehensive Protein Map of a Stem Cell. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/04/080404122202.htm
American Society for Biochemistry and Molecular Biology. "A Comprehensive Protein Map of a Stem Cell." ScienceDaily. www.sciencedaily.com/releases/2008/04/080404122202.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) — A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins