Featured Research

from universities, journals, and other organizations

Digestive Process Affects Anti-cancer Activity Of Tea In Gastrointestinal Cells

Date:
April 10, 2008
Source:
Federation of American Societies for Experimental Biology
Summary:
Increased consumption of teas rich in catechins is associated with reduced risk of stomach, colon and other gastrointestinal cancers. Now researchers have found found that the digestive process could both alter the structure of the tea catechins and their anticancer activity.

Increased consumption of teas rich in catechins is associated with reduced risk of stomach, colon and other gastrointestinal cancers. However, the effects of digestion on the anticancer activity of tea catechins have largely been ignored. A study by nutrition researchers at The Ohio State University and Purdue University found that the digestive process could both alter the structure of the tea catechins and their anticancer activity.

Fabiola Gutierrez Orozco, a graduate student in the laboratory of Dr. Joshua Bomser, The Ohio State University, presented study results on April 7 at Experimental Biology 2008 in San Diego. Other co-authors of the study are Dr. Marti Cenky of Ohio State; Dr. Mario G. Ferruzzi and Rodney Green, a graduate student in the Ferruzzi laboratory, of Purdue University. The presentation at Experimental Biology is part of the scientific program of the American Society for Nutrition.

Using a model simulating gastric and small-intestinal digestion, the researchers treated gastric cancer cells and colon cancer cell lines with digested and undigested (parent) extracts of green, tea, black tea, and a combination of the most active tea catechins (EGCG/EGC). In colon cells, digestion of both the green tea extracts and the catechin combination significantly reduced anticancer activity compared to undigested parent extracts. Black tea, on the other hand, showed the same anticancer activity for both parent and digested extracts.

Digestion and the type of tea made a difference in terms of anticancer activity. In addition, the anticancer activity of the tea extracts differed between gastric and colon cancer cell lines. In gastric cancer cells, the undigested extracts were 50 percent less effective than in colon cancer cells.

What does the new study show us?

First, says Dr. Bomser, it points out that better understanding the impact of digestion on tea could lead to changes in how we formulate products in order to protect and enhance their anticancer activity. It also could change how we prepare tea now. In a study from Dr. Ferruzzi's laboratory published last November, for example, he found that adding citrus (such as lemon juice) or ascorbic acid to green tea protected the catechins from digestive degradation. Lemon juice caused 80 percent of tea's catechins to remain available for the body to absorb.

Second, say the researchers, some of the digestive changes may impact anti-cancer activities. Work in Dr. Ferruzzi's laboratory has shown that digestion can alter the structure of polyphenols, degrading and destroying some while forming others. His laboratory is currently identifying these new compounds and testing their own anticancer activity.

Third, the findings of digestive impact on tea catechins are likely also true for other bioactive compounds in foods. Dr. Bomser points out that the active compound in broccoli, for example, is not released until chewing and the digestive process begins. How do we formulate food to prevent degradation and perhaps enhance anti-cancer activity?

And fourth, say the researchers, the epidemiological findings of protective impact of teas rich in the unstable, easily degraded catechins may indicate that other compounds in tea are responsible, in part, for this anticancer activity. Further research is necessary to identify these compounds and to understand the impact of digestion on their anticancer activity.

Funding for this work comes from the National Cancer Institute.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "Digestive Process Affects Anti-cancer Activity Of Tea In Gastrointestinal Cells." ScienceDaily. ScienceDaily, 10 April 2008. <www.sciencedaily.com/releases/2008/04/080407172713.htm>.
Federation of American Societies for Experimental Biology. (2008, April 10). Digestive Process Affects Anti-cancer Activity Of Tea In Gastrointestinal Cells. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2008/04/080407172713.htm
Federation of American Societies for Experimental Biology. "Digestive Process Affects Anti-cancer Activity Of Tea In Gastrointestinal Cells." ScienceDaily. www.sciencedaily.com/releases/2008/04/080407172713.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins