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Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days

Date:
May 21, 2008
Source:
Cardiovascular Research Foundation
Summary:
The HORIZONS AMI trial which showed the use of the anticoagulant bivalirudin following angioplasty in heart attack patients reduced net adverse clinical events by 24 percent compared to the standard treatment, as well as reduced the risk of overall mortality by 33 percent and cardiac mortality by 38 percent.

The New England Journal of Medicine has published results of the HORIZONS AMI trial which showed the use of the anticoagulant bivalirudin following angioplasty in heart attack patients reduced net adverse clinical events by 24 percent compared to the standard treatment, as well as reduced the risk of overall mortality by 33 percent and cardiac mortality by 38 percent.

The study, led by Gregg Stone, M.D., Chairman of the Cardiovascular Research Foundation and professor of medicine at Columbia University Medical Center/New York-Presbyterian Hospital, compared bivalirudin to heparin plus glycoprotein IIb/IIIa inhibitors in more than 3,600 patients with the most severe form of heart attack called ST-elevation myocardial infarction (STEMI).

The CRF-sponsored trial is the largest study to focus on the appropriate use of anticoagulation medications and drug-eluting stents in STEMI patients. It was also named one of the "Top Ten Research Advances" for 2007 by the American Heart Association.

"The HORIZONS AMI data show that using bivalirudin instead of heparin with a GPI during angioplasty markedly reduced major bleeding and other complications, and thereby improved survival in patients with heart attacks," said Dr. Stone. "As the first large-scale study in decades to show a reduction in death in patients with heart attack, we expect this new therapy, which is simple to use and cost-effective, to rapidly become widely adopted around the world."

Dr. Stone emphasized the importance of reducing the risk of bleeding. "This study demonstrated that bivalirudin use is safer than previous standard anticoagulant therapy, effectively preventing the ischemic complications of AMI without causing excess bleeding or other blood disturbances. Bleeding is a strong predictor of short and long-term mortality in patients undergoing angioplasty, and its prevention may be directly linked to the improved survival we observed with bivalirudin in high risk heart attack patients in this trial."

Patients enrolled in the HORIZONS AMI trial were also randomly assigned to receive either Taxus drug-eluting stents or a bare-metal stent. Data on this portion of the study -- also a landmark comparison of drug-eluting stents to bare-metal stents -- will be available in October at CRF's annual scientific symposium, TCT 2008.

About HORIZONS AMI

HORIZONS AMI, sponsored and independently run by the Cardiovascular Research Foundation with funding by grants from Boston Scientific and The Medicines Company, is the largest study to focus on the appropriate use of anticoagulation medications in patients experiencing STEMI and undergoing angioplasty. The trial is a prospective, single-blind, randomized, multicenter study conducted in 11 countries. A total of 3,604 patients undergoing angioplasty were randomly assigned to receive either bivalirudin with provisional use of GPI or heparin plus GPI.

The two primary endpoints of the trial were major bleeding and net adverse clinical events, a composite of major cardiovascular events (death, reinfarction, stroke or ischemic target vessel revascularization) or major bleeding at 30 days. The secondary endpoint was major adverse cardiovascular events at 30 days.


Story Source:

The above story is based on materials provided by Cardiovascular Research Foundation. Note: Materials may be edited for content and length.


Cite This Page:

Cardiovascular Research Foundation. "Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days." ScienceDaily. ScienceDaily, 21 May 2008. <www.sciencedaily.com/releases/2008/05/080521171812.htm>.
Cardiovascular Research Foundation. (2008, May 21). Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2008/05/080521171812.htm
Cardiovascular Research Foundation. "Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days." ScienceDaily. www.sciencedaily.com/releases/2008/05/080521171812.htm (accessed September 1, 2014).

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