Featured Research

from universities, journals, and other organizations

Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days

Date:
May 21, 2008
Source:
Cardiovascular Research Foundation
Summary:
The HORIZONS AMI trial which showed the use of the anticoagulant bivalirudin following angioplasty in heart attack patients reduced net adverse clinical events by 24 percent compared to the standard treatment, as well as reduced the risk of overall mortality by 33 percent and cardiac mortality by 38 percent.

The New England Journal of Medicine has published results of the HORIZONS AMI trial which showed the use of the anticoagulant bivalirudin following angioplasty in heart attack patients reduced net adverse clinical events by 24 percent compared to the standard treatment, as well as reduced the risk of overall mortality by 33 percent and cardiac mortality by 38 percent.

The study, led by Gregg Stone, M.D., Chairman of the Cardiovascular Research Foundation and professor of medicine at Columbia University Medical Center/New York-Presbyterian Hospital, compared bivalirudin to heparin plus glycoprotein IIb/IIIa inhibitors in more than 3,600 patients with the most severe form of heart attack called ST-elevation myocardial infarction (STEMI).

The CRF-sponsored trial is the largest study to focus on the appropriate use of anticoagulation medications and drug-eluting stents in STEMI patients. It was also named one of the "Top Ten Research Advances" for 2007 by the American Heart Association.

"The HORIZONS AMI data show that using bivalirudin instead of heparin with a GPI during angioplasty markedly reduced major bleeding and other complications, and thereby improved survival in patients with heart attacks," said Dr. Stone. "As the first large-scale study in decades to show a reduction in death in patients with heart attack, we expect this new therapy, which is simple to use and cost-effective, to rapidly become widely adopted around the world."

Dr. Stone emphasized the importance of reducing the risk of bleeding. "This study demonstrated that bivalirudin use is safer than previous standard anticoagulant therapy, effectively preventing the ischemic complications of AMI without causing excess bleeding or other blood disturbances. Bleeding is a strong predictor of short and long-term mortality in patients undergoing angioplasty, and its prevention may be directly linked to the improved survival we observed with bivalirudin in high risk heart attack patients in this trial."

Patients enrolled in the HORIZONS AMI trial were also randomly assigned to receive either Taxus drug-eluting stents or a bare-metal stent. Data on this portion of the study -- also a landmark comparison of drug-eluting stents to bare-metal stents -- will be available in October at CRF's annual scientific symposium, TCT 2008.

About HORIZONS AMI

HORIZONS AMI, sponsored and independently run by the Cardiovascular Research Foundation with funding by grants from Boston Scientific and The Medicines Company, is the largest study to focus on the appropriate use of anticoagulation medications in patients experiencing STEMI and undergoing angioplasty. The trial is a prospective, single-blind, randomized, multicenter study conducted in 11 countries. A total of 3,604 patients undergoing angioplasty were randomly assigned to receive either bivalirudin with provisional use of GPI or heparin plus GPI.

The two primary endpoints of the trial were major bleeding and net adverse clinical events, a composite of major cardiovascular events (death, reinfarction, stroke or ischemic target vessel revascularization) or major bleeding at 30 days. The secondary endpoint was major adverse cardiovascular events at 30 days.


Story Source:

The above story is based on materials provided by Cardiovascular Research Foundation. Note: Materials may be edited for content and length.


Cite This Page:

Cardiovascular Research Foundation. "Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days." ScienceDaily. ScienceDaily, 21 May 2008. <www.sciencedaily.com/releases/2008/05/080521171812.htm>.
Cardiovascular Research Foundation. (2008, May 21). Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/05/080521171812.htm
Cardiovascular Research Foundation. "Superiority Of Bivalirudin Found In Heart Attack Patients At 30 Days." ScienceDaily. www.sciencedaily.com/releases/2008/05/080521171812.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins