Featured Research

from universities, journals, and other organizations

New Method Identifies Rat Poison In Humans

Date:
May 28, 2008
Source:
Norwegian Institute of Public Health
Summary:
Researchers have developed a method to identify bromadiolone poisoning in humans. Bromadiolone is a rat poison that can be purchased freely in shops. A number of cases have been reported internationally where people have been poisoned, with a mortality rate of 20 percent.

Researchers at the Norwegian Institute of Public Health (NIPH) have developed a method to identify bromadiolone poisoning in humans. Bromadiolone is a rat poison that can be purchased freely in shops. A number of cases have been reported internationally where people have been poisoned, with a mortality rate of 20 percent.

Related Articles


Blood-thinning substances have been used for many years as rodenticides. Warfarin was previously used but due to resistance development, the so-called super-warfarins were introduced. These substances are 100 times as potent as warfarin.

A commonly used super-warfarin is bromadiolone (sold as the brand name Temus in Norway). Few laboratories have been able to prove the presence of bromadiolone in human samples and little is known what happens to the substance in the human body.

Now researchers at the NIPH have developed an analysis method to spot the presence of bromadiolone. The cause of serious bleeding disturbances in a female patient was investigated during a recent poisoning case. It appeared that the woman had been exposed to blood-thinning substances. Blood samples uncovered that she had been repeatedly exposed to bromadiolone.

The researchers discovered that bromadiolone is present in blood for a much shorter time than expected. The concentration of bromadiolone is higher in blood plasma than in whole blood, which is important to note when samples in different media are interpreted. After storage of the blood samples in the freezer at -20 degrees Celsius, followed by thawing for reanalysis, the concentration of bromadiolone fell over time.

In order to treat bleeding disorders, the cause of the patient’s condition must be identified as soon as possible. When poisoning with blood-thinning substances is suspected, an analysis method that can identify the superwarfarin bromadiolone, plus other superwarfarins and blood-thinning substances, is now available.


Story Source:

The above story is based on materials provided by Norwegian Institute of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vindenes et al. Bromadiolone Poisoning: LC-MS Method and Pharmacokinetic Data. Journal of Forensic Sciences, 2008; 0 (0): 080509070141841 DOI: 10.1111/j.1556-4029.2008.00737.x

Cite This Page:

Norwegian Institute of Public Health. "New Method Identifies Rat Poison In Humans." ScienceDaily. ScienceDaily, 28 May 2008. <www.sciencedaily.com/releases/2008/05/080527094142.htm>.
Norwegian Institute of Public Health. (2008, May 28). New Method Identifies Rat Poison In Humans. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2008/05/080527094142.htm
Norwegian Institute of Public Health. "New Method Identifies Rat Poison In Humans." ScienceDaily. www.sciencedaily.com/releases/2008/05/080527094142.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins