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Protein Found To Promote Antibiotic Resistance In A Common Food-borne Pathogen

Date:
June 8, 2008
Source:
Public Library of Science
Summary:
Researchers have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen. The study explains that Mfd, a protein involved in DNA transcription and repair, plays an important role in the development of fluoroquinolone resistance in Campylobacter, a bacterial pathogen commonly associated with food poisoning in humans.

Researchers from Iowa State University have identified a novel factor that promotes the development of antibiotic resistance in a bacterial pathogen. The study explains that Mfd, a protein involved in DNA transcription and repair, plays an important role in the development of fluoroquinolone resistance in Campylobacter, a bacterial pathogen commonly associated with food poisoning in humans.

Development of antibiotic resistance in Campylobacter, especially to fluoroquinolone (a broad-spectrum antimicrobial), compromises clinical therapy and poses a public health threat. Previous studies have revealed that Campylobacter is highly mutable to antibiotic treatment and the number of fluoroquinolone-resistant Campylobacter is greatly increased in many regions of the world. But it has not been clear why Campylobacter is able to mutate at such a high frequency.

Using various molecular tools, the research team from the College of Veterinary Medicine, led by Dr. Qijing Zhang, has found that Campylobacter increases the production of Mfd in the presence of a fluoroquinolone antibiotic. Elimination of Mfd from Campylobacter resulted in 100-fold reduction in the rate of emergence of mutants resistant to fluoroquinolones. Without Mfd, the development of fluoroquinolone-resistant Campylobacter under antibiotic treatment is significantly reduced.

These findings have uncovered a previously unrecognized role of Mfd in promoting mutations conferring antibiotic resistance. Despite its importance, Mfd is not the only factor influencing the mutation frequency and future studies will be needed to determine how Mfd increases the emergence of antibiotic-resistant mutants.



Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Han J, Sahin O, Barton Y-W, Zhang Q. Key Role of Mfd in the Development of Fluoroquinolone Resistance in Campylobacter jejuni. PLoS Pathogens, 4(6): e1000083 [link]

Cite This Page:

Public Library of Science. "Protein Found To Promote Antibiotic Resistance In A Common Food-borne Pathogen." ScienceDaily. ScienceDaily, 8 June 2008. <www.sciencedaily.com/releases/2008/06/080605200445.htm>.
Public Library of Science. (2008, June 8). Protein Found To Promote Antibiotic Resistance In A Common Food-borne Pathogen. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/06/080605200445.htm
Public Library of Science. "Protein Found To Promote Antibiotic Resistance In A Common Food-borne Pathogen." ScienceDaily. www.sciencedaily.com/releases/2008/06/080605200445.htm (accessed October 21, 2014).

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