Featured Research

from universities, journals, and other organizations

Hox Genes Control Path Of Neurons Responsible For Nervous System Development

Date:
June 16, 2008
Source:
Public Library of Science
Summary:
Scientists demonstrate that pontine neuron migration in mice is controlled by specific Hox genes. They show that by knocking out the expression of the Hoxa2 gene the path of the neurons changes, causing them to end up in the wrong part of the brain.

In this whole-mount lateral view of an embryonic day 17.5 mouse brain, an EGFP knock-in allele into the Hoxa2 locus allows direct visualization of pontine neurons during their migration and to their final destination in the anteroventral brain stem.
Credit: Rijli et al.

Pontine neurons are generated in the rear part of the brain and ultimately end up in the cerebellum, a region in the brain responsible for coordinating the senses and motor functions in the body. How these neurons make the journey across the brain has, until now, been somewhat of a mystery. In a new paper authors Filippo Rijli and colleagues demonstrate that pontine neuron migration in mice is controlled by specific Hox genes. They show that by knocking out the expression of the Hoxa2 gene the path of the neurons changes, causing them to end up in the wrong part of the brain.

Hox genes are crucial in the orchestration of organized growth in organisms ranging from plants to humans. The authors have identified a specific Hox gene, Hoxa2, which controls the pontine neurons' responsiveness to chemicals that attract and repel them, thus telling them where to go in the brain. The authors found that when the Hoxa2 gene was knocked out, the pontine neurons went to the bottom of the brainstem instead of going to the cerebellum.

To explain in detail, the Hoxa2 gene controls expression of the receptor, Robo. Robo is bound to the chemical, Slit, which prevents migrating neurons from responding to chemoattractants. The authors found that in knocking out Hoxa2, pontine neurons become insensitive to Slit signaling: the neurons ignore the repellant signal and head prematurely toward the chemoattractant, guiding them into the wrong part of the brain. The study also shows that the absence of Slit or Robo causes the same type of abnormal migrations caused by the absence of Hoxa2--further evidence that all three are integral to the same system.

Although this paper resolves some of the mystery of the neuron migration route, there is still more to explore. The authors found that not all neurons react to a loss of Hoxa2, suggesting these genes function in a specific manner and opening the search for other Hox genes that affect neuronal migration and the development of the mammalian brain.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Geisen et al. Hox Paralog Group 2 Genes Control the Migration of Mouse Pontine Neurons through Slit-Robo Signaling. PLoS Biology, 2008; 6 (6): e142 DOI: 10.1371/journal.pbio.0060142

Cite This Page:

Public Library of Science. "Hox Genes Control Path Of Neurons Responsible For Nervous System Development." ScienceDaily. ScienceDaily, 16 June 2008. <www.sciencedaily.com/releases/2008/06/080610092756.htm>.
Public Library of Science. (2008, June 16). Hox Genes Control Path Of Neurons Responsible For Nervous System Development. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2008/06/080610092756.htm
Public Library of Science. "Hox Genes Control Path Of Neurons Responsible For Nervous System Development." ScienceDaily. www.sciencedaily.com/releases/2008/06/080610092756.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins