Featured Research

from universities, journals, and other organizations

Hox Genes Control Path Of Neurons Responsible For Nervous System Development

Date:
June 16, 2008
Source:
Public Library of Science
Summary:
Scientists demonstrate that pontine neuron migration in mice is controlled by specific Hox genes. They show that by knocking out the expression of the Hoxa2 gene the path of the neurons changes, causing them to end up in the wrong part of the brain.

In this whole-mount lateral view of an embryonic day 17.5 mouse brain, an EGFP knock-in allele into the Hoxa2 locus allows direct visualization of pontine neurons during their migration and to their final destination in the anteroventral brain stem.
Credit: Rijli et al.

Pontine neurons are generated in the rear part of the brain and ultimately end up in the cerebellum, a region in the brain responsible for coordinating the senses and motor functions in the body. How these neurons make the journey across the brain has, until now, been somewhat of a mystery. In a new paper authors Filippo Rijli and colleagues demonstrate that pontine neuron migration in mice is controlled by specific Hox genes. They show that by knocking out the expression of the Hoxa2 gene the path of the neurons changes, causing them to end up in the wrong part of the brain.

Hox genes are crucial in the orchestration of organized growth in organisms ranging from plants to humans. The authors have identified a specific Hox gene, Hoxa2, which controls the pontine neurons' responsiveness to chemicals that attract and repel them, thus telling them where to go in the brain. The authors found that when the Hoxa2 gene was knocked out, the pontine neurons went to the bottom of the brainstem instead of going to the cerebellum.

To explain in detail, the Hoxa2 gene controls expression of the receptor, Robo. Robo is bound to the chemical, Slit, which prevents migrating neurons from responding to chemoattractants. The authors found that in knocking out Hoxa2, pontine neurons become insensitive to Slit signaling: the neurons ignore the repellant signal and head prematurely toward the chemoattractant, guiding them into the wrong part of the brain. The study also shows that the absence of Slit or Robo causes the same type of abnormal migrations caused by the absence of Hoxa2--further evidence that all three are integral to the same system.

Although this paper resolves some of the mystery of the neuron migration route, there is still more to explore. The authors found that not all neurons react to a loss of Hoxa2, suggesting these genes function in a specific manner and opening the search for other Hox genes that affect neuronal migration and the development of the mammalian brain.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Geisen et al. Hox Paralog Group 2 Genes Control the Migration of Mouse Pontine Neurons through Slit-Robo Signaling. PLoS Biology, 2008; 6 (6): e142 DOI: 10.1371/journal.pbio.0060142

Cite This Page:

Public Library of Science. "Hox Genes Control Path Of Neurons Responsible For Nervous System Development." ScienceDaily. ScienceDaily, 16 June 2008. <www.sciencedaily.com/releases/2008/06/080610092756.htm>.
Public Library of Science. (2008, June 16). Hox Genes Control Path Of Neurons Responsible For Nervous System Development. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2008/06/080610092756.htm
Public Library of Science. "Hox Genes Control Path Of Neurons Responsible For Nervous System Development." ScienceDaily. www.sciencedaily.com/releases/2008/06/080610092756.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins