Featured Research

from universities, journals, and other organizations

Evalve MitraClip: Clinical Trial Of Nonsurgical Repair For Severe Mitral Valve Regurgitation

Date:
June 19, 2008
Source:
Cedars-Sinai Medical Center
Summary:
The Everest II Clinical Trial is a study comparing nonsurgical repair for severe mitral valve regurgitation with conventional surgery. The MitraClip procedure is performed in a cardiac catheterization laboratory with the patient under general anesthesia. A thin, flexible tube (catheter) is inserted through a small incision in the groin and guided through the femoral vein to the affected area of the heart.

The Cedars-Sinai Heart Institute is the lead enroller in the world for the Everest II Clinical Trial -- a study comparing non-surgical repair for severe mitral valve regurgitation with conventional surgery. In 2005, a team of doctors at the Institute implanted the first Evalve MitraClip™ in California, and was also first on the West Coast to insert two clips during a single procedure. Cedars-Sinai is believed to be the most experienced center in the nation with any form of percutaneous mitral valve repair.

About four million Americans have significant mitral valve regurgitation, with 250,000 new patients diagnosed each year.

The mitral valve consists of two "leaflets" that act as swinging doors between the left atrium and the left ventricle. If the valve fails to close properly, blood flows backward into the atrium (regurgitation), leaving the left ventricle, the heart's primary pumping chamber, with too little blood. To compensate, the ventricle stretches and overworks. Over time, it undergoes a process called remodeling, becoming enlarged, distorted and weak.

The MitraClip procedure is performed in a cardiac catheterization laboratory with the patient under general anesthesia. A thin, flexible tube (catheter) is inserted through a small incision in the groin and guided through the femoral vein to the affected area of the heart. A smaller catheter holding the clip is slipped through the first catheter. After the clip is attached to the valve leaflets, the catheters are removed. The patient is released from the hospital within a day or two.

While the procedure is complex and challenging, requiring a coordinated effort among echocardiographers, interventional cardiologists, anesthesiologists and other team members, it is also somewhat forgiving. If the clip is not placed ideally on the first attempt, it can be reset. If it does not sufficiently correct the regurgitation, surgical repair or replacement of the valve remains an option.

Results from studies so far show that the MitraClip can provide successful reduction of mitral regurgitation for up to 36 months. Also, studies showed that with resumption of proper valve function, left ventricular remodeling was significantly improved at 12-month follow-up.

Traditional surgery is still the best option in extremely difficult cases or when the annulus, the ring-shaped structure to which the leaflets are attached, needs repair. Cedars-Sinai's Center for Valvular Intervention, one of the largest heart valve programs in the western United States, combines the expertise of cardiologists and cardiothoracic surgeons to offer a wide range of surgical and non-surgical repair and replacement procedures.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Evalve MitraClip: Clinical Trial Of Nonsurgical Repair For Severe Mitral Valve Regurgitation." ScienceDaily. ScienceDaily, 19 June 2008. <www.sciencedaily.com/releases/2008/06/080619090742.htm>.
Cedars-Sinai Medical Center. (2008, June 19). Evalve MitraClip: Clinical Trial Of Nonsurgical Repair For Severe Mitral Valve Regurgitation. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/06/080619090742.htm
Cedars-Sinai Medical Center. "Evalve MitraClip: Clinical Trial Of Nonsurgical Repair For Severe Mitral Valve Regurgitation." ScienceDaily. www.sciencedaily.com/releases/2008/06/080619090742.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins