Featured Research

from universities, journals, and other organizations

12 Million Molecules Share 143 Basic Shapes, Researchers Find

Date:
June 23, 2008
Source:
American Chemical Society
Summary:
Chemists in Ohio have discovered that half of all of the known chemical compounds in the world have an amazing similarity in sharing only 143 basic molecular shapes.

Chemists in Ohio have discovered that half of all of the known chemical compounds in the world have an amazing similarity in sharing only 143 basic molecular shapes.

Related Articles


That sharply limits the number of molecular building blocks that chemists often deploy in efforts to develop new drugs and other products, the researchers say in a study scheduled for the June 20 issue of the bi-weekly ACS' Journal of Organic Chemistry.

Alan H. Lipkus and colleagues note that researchers have known for years that certain features of molecules, such as rings of atoms and the bonds than link them together, appear time after time in hundreds of life-saving medications, food additives, and other widely used products.

Scientists often tend to focus on these well-known types of molecular scaffolding in their quest to select the most promising rings, linkers, and other components for building new drugs while overlooking less familiar structures, the researchers say.

In the new study, they analyzed the chemical frameworks of more than 24 million organic substances found in the ACS' Chemical Abstracts Service (CAS) Registry, the world's most comprehensive database of disclosed molecules. They found that half of the substances could be described by only 143 basic framework shapes. By paying more attention to a multitude of other molecular shapes, chemists might discover an array of useful rings, linkers, and other building blocks for tomorrow's drugs and other medical, commercial, and industrial products, the study concluded.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lipkus, Alan H., Yuan, Qiong, Lucas, Karen A., Funk, Susan A., Bartelt, William F., Schenck, Roger J., and Trippe, Anthony J. Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry. J. Org. Chem., 73, 12, 4443 - 4451, 2008 DOI: 10.1021/jo8001276

Cite This Page:

American Chemical Society. "12 Million Molecules Share 143 Basic Shapes, Researchers Find." ScienceDaily. ScienceDaily, 23 June 2008. <www.sciencedaily.com/releases/2008/06/080623093425.htm>.
American Chemical Society. (2008, June 23). 12 Million Molecules Share 143 Basic Shapes, Researchers Find. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2008/06/080623093425.htm
American Chemical Society. "12 Million Molecules Share 143 Basic Shapes, Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2008/06/080623093425.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bionic Ants Could Be Tomorrow's Factory Workers

Bionic Ants Could Be Tomorrow's Factory Workers

Reuters - Innovations Video Online (Mar. 30, 2015) Industrious 3D printed bionic ants working together could toil in the factories of the future, says German technology company Festo. The robotic insects cooperate and coordinate their actions and movements to achieve a common aim. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com
You Won't Be Driving Tesla's Mystery Product

You Won't Be Driving Tesla's Mystery Product

Newsy (Mar. 30, 2015) Tesla CEO Elon Musk announced a new product line will debut April 30, but it&apos;s not a car. Video provided by Newsy
Powered by NewsLook.com
Solar Impulse Departs Myanmar for China

Solar Impulse Departs Myanmar for China

AFP (Mar. 30, 2015) Solar Impulse 2 takes off from Myanmar&apos;s second biggest city of Mandalay and heads for China&apos;s Chongqing, the fifth flight of a landmark journey to circumnavigate the globe powered solely by the sun. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Internet Giants Drive Into the Electric Vehicle Space

Internet Giants Drive Into the Electric Vehicle Space

Reuters - Business Video Online (Mar. 30, 2015) Internet companies are looking to disrupt the auto industry with new smart e-vehicles, but widespread adoption in Asia may not be cured by new Chinese investments. Pamela Ambler reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins