Featured Research

from universities, journals, and other organizations

12 Million Molecules Share 143 Basic Shapes, Researchers Find

Date:
June 23, 2008
Source:
American Chemical Society
Summary:
Chemists in Ohio have discovered that half of all of the known chemical compounds in the world have an amazing similarity in sharing only 143 basic molecular shapes.

Chemists in Ohio have discovered that half of all of the known chemical compounds in the world have an amazing similarity in sharing only 143 basic molecular shapes.

That sharply limits the number of molecular building blocks that chemists often deploy in efforts to develop new drugs and other products, the researchers say in a study scheduled for the June 20 issue of the bi-weekly ACS' Journal of Organic Chemistry.

Alan H. Lipkus and colleagues note that researchers have known for years that certain features of molecules, such as rings of atoms and the bonds than link them together, appear time after time in hundreds of life-saving medications, food additives, and other widely used products.

Scientists often tend to focus on these well-known types of molecular scaffolding in their quest to select the most promising rings, linkers, and other components for building new drugs while overlooking less familiar structures, the researchers say.

In the new study, they analyzed the chemical frameworks of more than 24 million organic substances found in the ACS' Chemical Abstracts Service (CAS) Registry, the world's most comprehensive database of disclosed molecules. They found that half of the substances could be described by only 143 basic framework shapes. By paying more attention to a multitude of other molecular shapes, chemists might discover an array of useful rings, linkers, and other building blocks for tomorrow's drugs and other medical, commercial, and industrial products, the study concluded.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lipkus, Alan H., Yuan, Qiong, Lucas, Karen A., Funk, Susan A., Bartelt, William F., Schenck, Roger J., and Trippe, Anthony J. Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry. J. Org. Chem., 73, 12, 4443 - 4451, 2008 DOI: 10.1021/jo8001276

Cite This Page:

American Chemical Society. "12 Million Molecules Share 143 Basic Shapes, Researchers Find." ScienceDaily. ScienceDaily, 23 June 2008. <www.sciencedaily.com/releases/2008/06/080623093425.htm>.
American Chemical Society. (2008, June 23). 12 Million Molecules Share 143 Basic Shapes, Researchers Find. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2008/06/080623093425.htm
American Chemical Society. "12 Million Molecules Share 143 Basic Shapes, Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2008/06/080623093425.htm (accessed September 22, 2014).

Share This



More Matter & Energy News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Company Copies Keys From Photos

Company Copies Keys From Photos

Newsy (Sep. 22, 2014) A new company allows customers to make copies of keys by simply uploading a couple of photos. But could it also be great for thieves? Video provided by Newsy
Powered by NewsLook.com
Raw: SpaceX Rocket Carries 3-D Printer to Space

Raw: SpaceX Rocket Carries 3-D Printer to Space

AP (Sep. 22, 2014) A SpaceX Rocket launched from Cape Canaveral, carrying a custom-built 3-D printer into space. NASA envisions astronauts one day using the printer to make their own spare parts. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Inside London's Massive Sewer Tunnel Project

Inside London's Massive Sewer Tunnel Project

AP (Sep. 22, 2014) Billions of dollars are being spent on a massive super sewer to take away London's vast output of waste, which is endangering the River Thames. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Thousands March in NYC Over Climate Change

Thousands March in NYC Over Climate Change

AP (Sep. 21, 2014) Accompanied by drumbeats, wearing costumes and carrying signs, thousands of demonstrators filled the streets of Manhattan and other cities around the world on Sunday to urge policy makers to take action on climate change. (Sept. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins