Featured Research

from universities, journals, and other organizations

Integrins As Receptors Give Insight Into Rotavirus And Diarrhea

Date:
July 2, 2008
Source:
Baylor College of Medicine
Summary:
Eleven years ago, scientists discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhea. The next step was to find the cellular receptor on intestinal cells through which the enterotoxin interacts to cause diarrhea.

Eleven years ago, Dr. Mary Estes of Baylor College of Medicine and her colleagues discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhea.

The next step was to find the cellular receptor on intestinal cells through which the enterotoxin interacts to cause diarrhea.

"We knew that identifying the receptor might not be straightforward," said the professor of molecular virology and microbiology at BCM. In a new article, Estes and her colleagues describe two receptors for the enterotoxin, both of them integrins.

The two, integrin alpha1 beta1 and integrin alpha2 beta1, are members of a class of molecules that are involved in attaching cells to other cells and to the extracellular matrix (a part of tissue that is not part of any cell). Integrins also are involved in transforming or translating cell signals.

In looking for the receptor, Estes and her colleagues also learned more about the enterotoxin itself.

"It's a new ligand for binding to integrins," she said. "It begins to give us an understanding of how the enterotoxin works in the intestine. Two different domains of the enterotoxin are involved in this interaction. One domain is for binding and the other domain is for signaling through the receptor."

She said she hopes to study the signaling aspect of the enterotoxin more closely because it could hold the clue to the mechanism of induction of diarrheal disease.

"There may be ways to block the interaction between the enterotoxin and the receptor to treat diarrheal disease," said Estes, who is also director of the Texas Medical Center Digestive Diseases Center.

Rotavirus is one of the most common causes of diarrhea, resulting in approximately 3 million cases of diarrhea and 55,000 hospitalizations for diarrhea and dehydration in children under the age of 5 each year in the United States alone. Worldwide, it causes nearly half a million deaths each year. Finding out how rotavirus causes diarrhea and looking for ways to block it is a major aim of Estes' research.

Others who took part in this work include Carl Q.-Y. Zeng, Joseph M. Hyser, Budi Utama and Sue E. Crawford of BCM, Neung-Seon Seo, Kate J. Kim and Magnus Hőők of Texas A&M University Health Science Center at Houston.

Funding for this work came from the National Institutes of Health, including a grant that funds the Texas Medical Center Digestive Diseases Center.

 


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Neung-Seon Seo, Carl Q.-Y. Zeng, Joseph M. Hyser, Budi Utama, Sue E. Crawford, Kate J. Kim, Magnus Höök, and Mary K. Estes. Inaugural Article: Integrins 1β1 and {alpha}2β1 are receptors for the rotavirus enterotoxin. PNAS, June 27, 2008 DOI: 10.1073/pnas.0803934105

Cite This Page:

Baylor College of Medicine. "Integrins As Receptors Give Insight Into Rotavirus And Diarrhea." ScienceDaily. ScienceDaily, 2 July 2008. <www.sciencedaily.com/releases/2008/06/080630120128.htm>.
Baylor College of Medicine. (2008, July 2). Integrins As Receptors Give Insight Into Rotavirus And Diarrhea. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2008/06/080630120128.htm
Baylor College of Medicine. "Integrins As Receptors Give Insight Into Rotavirus And Diarrhea." ScienceDaily. www.sciencedaily.com/releases/2008/06/080630120128.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
 
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins