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First DNA Molecule Made Almost Entirely Of Artificial Parts

Date:
July 7, 2008
Source:
American Chemical Society
Summary:
Chemists in Japan report development of the world's first DNA molecule made almost entirely of artificial parts. The finding could lead to improvements in gene therapy, futuristic nano-sized computers, and other high-tech advances, they say.

Scientists are reporting synthesis of the world's first DNA molecule made almost of entirely artificial parts. The discovery could be used in the fields of gene therapy and other futuristic high-tech advances, such as nano-sized computers.
Credit: Courtesy of Masahiko Inouye

Chemists in Japan report development of the world's first DNA molecule made almost entirely of artificial parts. The finding could lead to improvements in gene therapy, futuristic nano-sized computers, and other high-tech advances, they say.

In the new study, Masahiko Inouye and colleagues point out that scientists have tried for years to develop artificial versions of DNA in order to extend its amazing information storage capabilities.

As the genetic blueprint of all life forms, DNA uses the same set of four basic building blocks, known as bases, to code for a variety of proteins used in cell functioning and development. Until now, scientists have only been able to craft DNA molecules with one or a few artificial parts, including certain bases.

The researchers used high-tech DNA synthesis equipment to stitch together four entirely new, artificial bases inside the sugar-based framework of a DNA molecule. This resulted in unusually stable, double-stranded structures resembling natural DNA.

Like natural DNA, the new structures were right-handed and some easily formed triple-stranded structures. The unique chemistry of these structures and their high stability offer unprecedented possibilities for developing new biotech materials and applications, the researchers say.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Doi et al. Artificial DNA Made Exclusively of Nonnatural C-Nucleosides with Four Types of Nonnatural Bases. Journal of the American Chemical Society, 2008; 130 (27): 8762 DOI: 10.1021/ja801058h

Cite This Page:

American Chemical Society. "First DNA Molecule Made Almost Entirely Of Artificial Parts." ScienceDaily. ScienceDaily, 7 July 2008. <www.sciencedaily.com/releases/2008/07/080707091915.htm>.
American Chemical Society. (2008, July 7). First DNA Molecule Made Almost Entirely Of Artificial Parts. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/07/080707091915.htm
American Chemical Society. "First DNA Molecule Made Almost Entirely Of Artificial Parts." ScienceDaily. www.sciencedaily.com/releases/2008/07/080707091915.htm (accessed July 31, 2014).

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